{"id":"W2266707315","doi":"10.1038/nn.4236","title":"Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity","year":2016,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":270,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotchkiss Brain Institute; University of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research; University of Alberta; University of Calgary","keywords":"Excitotoxicity; Pannexin; NMDA receptor; Neuroscience; Neuroprotection; Ionotropic effect; Long-term depression; Cell biology; Glutamate receptor; Metabotropic receptor; Chemistry; Receptor; Biology; AMPA receptor; Biochemistry; Gap junction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001439222,0.0002078837,0.0001765609,0.00007927865,0.0001901598,0.0000359259,0.0004840057,0.0002577011,0.00002279201],"category_scores_gemma":[0.0007210373,0.0001414259,0.00009223844,0.0002397762,0.0001692703,0.00001033152,0.0002404741,0.0001880094,0.0000191091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001801103,"about_ca_system_score_gemma":0.00006336162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008438367,"about_ca_topic_score_gemma":0.00001580588,"domain_scores_codex":[0.9983051,0.00007644925,0.0001895747,0.0007778431,0.0002011242,0.0004499305],"domain_scores_gemma":[0.9991975,0.00003947792,0.00007234867,0.0004223895,0.000100592,0.0001677012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007174491,0.00002719492,0.001983657,0.000005385017,0.000003154899,0.00000352966,0.000007915228,0.00001569836,0.9958388,0.00009190889,0.0004610722,0.001489926],"study_design_scores_gemma":[0.0002637433,0.0002577926,0.03268919,0.00001853402,0.000003087498,0.000007401355,0.00001345456,0.00000377942,0.8838304,0.00001545432,0.08267977,0.0002173485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966765,0.0006005926,0.0008310748,0.0005946498,0.0009112129,0.0001876795,0.00005210043,0.00003679323,0.0001093806],"genre_scores_gemma":[0.9955961,0.0002716768,0.0003060767,0.002676194,0.0004227406,0.0000210083,0.000004250088,0.00001862348,0.000683306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1120084,"threshold_uncertainty_score":0.5767179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009843524594682443,"score_gpt":0.2518571798441873,"score_spread":0.2420136552495048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}