{"id":"W2267004994","doi":"10.1039/c5md00590f","title":"Aryl and heteroaryl <i>N</i>-[4-[4-(2,3-substituted-phenyl)piperazine-1-yl]alkyl]carbamates with improved physico-chemical properties as dual modulators of dopamine D3 receptor and fatty acid amide hydrolase","year":2016,"lang":"en","type":"article","venue":"MedChemComm","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Institute of Cancer Research","funders":"","keywords":"Piperazine; Aryl; Chemistry; Alkyl; Medicinal chemistry; Dopamine; Fatty acid; Combinatorial chemistry; Stereochemistry; Organic chemistry; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001622951,0.0002478122,0.0001826489,0.0001649391,0.0001278472,0.0001401998,0.000435679,0.000218972,0.002770395],"category_scores_gemma":[0.0001339926,0.0001121323,0.0001518233,0.0001614371,0.000150661,0.0003392109,0.0002524788,0.0003771927,0.0007698789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002057524,"about_ca_system_score_gemma":0.0001441316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003869684,"about_ca_topic_score_gemma":0.001223464,"domain_scores_codex":[0.9999362,0.0000124335,0.000004928419,0.00001256925,0.00001452543,0.00001939245],"domain_scores_gemma":[0.9999573,0.000004888136,0.00001520364,0.000005523696,0.000006766684,0.00001026926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005386305,0.00009012414,0.0001229886,0.0001991989,0.0000133222,0.0001716442,0.00004809293,0.0002267565,0.9793358,0.001446061,0.0009087314,0.01689865],"study_design_scores_gemma":[0.0001507688,0.002061153,0.002006342,0.00002613884,0.00003975004,0.0007138437,0.00004407475,0.001131859,0.9707258,0.000255911,0.02281479,0.00002941558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9508337,0.01054029,0.01221279,0.0005008412,0.0001965618,0.0001424919,0.0008232452,0.0003671993,0.02438277],"genre_scores_gemma":[0.9793657,0.005684966,0.005349194,0.0003043425,0.00005761595,0.00008001082,0.0004307943,0.00004045249,0.008686898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002770395,"threshold_uncertainty_score":0.009267867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009048834536528131,"score_gpt":0.2279210404857513,"score_spread":0.2188722059492232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}