{"id":"W2267080217","doi":"10.1371/journal.pone.0072138","title":"S100A8 and S100A9 Induce Cytokine Expression and Regulate the NLRP3 Inflammasome via ROS-Dependent Activation of NF-κB1","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":256,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research","keywords":"Inflammasome; S100A9; Pyrin domain; Secretion; Chemokine; Cytokine; Cell biology; Biology; Proinflammatory cytokine; NALP3; Inflammation; Immunology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001369232,0.0003951527,0.0002928011,0.000203343,0.0001270694,0.0002483103,0.0001036988,0.0003460432,0.001321407],"category_scores_gemma":[0.0001346521,0.0001388238,0.0003927873,0.0001487718,0.000246047,0.0002543608,0.0002483863,0.0005215844,0.0003667981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001937616,"about_ca_system_score_gemma":0.0001439669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002168846,"about_ca_topic_score_gemma":0.0003785058,"domain_scores_codex":[0.9998556,0.00002965324,0.000017437,0.00002671452,0.00004083941,0.00002971884],"domain_scores_gemma":[0.9999119,0.00001222533,0.00003503275,0.000007545653,0.00001221083,0.00002115964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002311055,0.00003813958,0.0002062654,0.00005804732,0.000009026081,0.00009244513,0.00001254137,0.00003767372,0.9977828,0.00006002682,0.00003542316,0.001436555],"study_design_scores_gemma":[0.00014058,0.0009427802,0.01741233,0.00002700166,0.00003283244,0.0008263167,0.00008947433,0.00161011,0.9738913,0.0003640469,0.004653245,0.000009926131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888432,0.005035275,0.003739259,0.0003121577,0.00007053799,0.00004608412,0.0002473031,0.00006767031,0.001638476],"genre_scores_gemma":[0.9912815,0.002065439,0.003760388,0.0001266163,0.00002419856,0.00008120719,0.0003221961,0.00001420058,0.002324268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001321407,"threshold_uncertainty_score":0.004420519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0114672446042923,"score_gpt":0.1918888736547363,"score_spread":0.180421629050444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}