{"id":"W2267080217","doi":"10.1371/journal.pone.0072138","title":"S100A8 and S100A9 Induce Cytokine Expression and Regulate the NLRP3 Inflammasome via ROS-Dependent Activation of NF-κB1","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":256,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research","keywords":"Inflammasome; S100A9; Pyrin domain; Secretion; Chemokine; Cytokine; Cell biology; Biology; Proinflammatory cytokine; NALP3; Inflammation; Immunology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001116253,0.0001309524,0.0001487566,0.00003494754,0.00008982149,0.00002640205,0.0001098133,0.0001340445,0.00002962173],"category_scores_gemma":[0.00006160349,0.00009789334,0.00002631081,0.00005051999,0.00009940111,0.00002053964,0.000167186,0.0001001076,0.000005463964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005556136,"about_ca_system_score_gemma":0.00001586901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004073887,"about_ca_topic_score_gemma":0.000004055962,"domain_scores_codex":[0.9992084,0.00004801761,0.0002031693,0.0002193426,0.0001581645,0.0001629421],"domain_scores_gemma":[0.9994118,0.00001581675,0.0001229273,0.0003057671,0.0001047315,0.00003897487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000530547,0.0001127509,0.002121316,0.00004440282,0.00007242697,2.178073e-7,0.0001317454,0.000004531637,0.9955118,0.00001610831,0.00006741972,0.001864282],"study_design_scores_gemma":[0.0005840238,0.0001572726,0.0231755,0.00006302814,0.0000271702,0.000002124527,0.000113317,0.00008872696,0.975222,0.0002089866,0.0002317551,0.0001260897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983094,0.0005102268,0.00007891376,0.0004261829,0.00001641779,0.0003478052,0.000003465253,0.000008254878,0.0002993079],"genre_scores_gemma":[0.9985365,0.0005366554,0.0001828682,0.000107096,0.00006751282,0.00004594522,0.00004596643,0.00001781809,0.0004596801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02105418,"threshold_uncertainty_score":0.3991975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0114672446042923,"score_gpt":0.1918888736547363,"score_spread":0.180421629050444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}