{"id":"W2267085599","doi":"10.1093/mutage/gev082","title":"The utility of metabolic activation mixtures containing human hepatic post-mitochondrial supernatant (S9) for<i>in vitro</i>genetic toxicity assessment","year":2015,"lang":"en","type":"review","venue":"Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada; Wilfrid Laurier University","funders":"Health Canada; Health and Environmental Sciences Institute; AstraZeneca","keywords":"S9 fraction; Genotoxicity; Ames test; Micronucleus; Potency; In vitro; Carcinogen; Micronucleus test; Toxicity; Chemistry; In vitro toxicology; Biochemistry; Pharmacology; Toxicology; Biology; Microsome; Salmonella; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008244824,0.0005314333,0.001422444,0.0001299331,0.000237497,0.00007181605,0.0005896111,0.0004372084,0.00001358062],"category_scores_gemma":[0.0001809133,0.0003991739,0.0007610032,0.0002060607,0.0001228239,0.000006505824,0.0002577783,0.0002089116,0.000001001803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009438748,"about_ca_system_score_gemma":0.000830247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003844662,"about_ca_topic_score_gemma":0.0004171483,"domain_scores_codex":[0.9967987,0.0005093489,0.001056166,0.0007283574,0.0004245387,0.0004828973],"domain_scores_gemma":[0.997884,0.0001645746,0.0005846585,0.0009152461,0.0003321258,0.0001193837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002997597,0.0002803152,0.0001507842,0.002398172,0.0006898434,0.000005837876,0.00007056697,0.000009382775,0.4936453,0.00008563139,0.0002159158,0.5021484],"study_design_scores_gemma":[0.001411954,0.0006901347,0.001595042,0.0005737079,0.001241156,0.00001878225,0.0001609272,0.000106835,0.2155035,0.00009167581,0.7777219,0.0008843921],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.09466325,0.9003658,0.001182119,0.00002672038,0.000407293,0.002533612,0.0006926098,0.00001117965,0.0001173994],"genre_scores_gemma":[0.1938715,0.8007752,0.001839575,0.00006053795,0.0006674887,0.0009554407,0.001581367,0.0001038943,0.0001449424],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.777506,"threshold_uncertainty_score":0.999846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03589937961083489,"score_gpt":0.350978397937705,"score_spread":0.3150790183268701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}