{"id":"W2267370236","doi":"10.1016/j.cell.2016.01.004","title":"Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis","year":2016,"lang":"en","type":"article","venue":"Cell","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":224,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"National Institutes of Health; Lawrence J. and Florence A. DeGeorge Charitable Trust; National Heart, Lung, and Blood Institute; Gladstone Institutes; Paul Scherrer Institut; National Center for Research Resources; American Heart Association","keywords":"Biology; Zinc finger; Transcription factor; GATA4; Ectopic expression; Homeobox; Cell biology; Genetics; Gene; Regulation of gene expression; Zinc finger transcription factor; Cell fate determination; Computational biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002482753,0.0004058257,0.0004721284,0.0008221117,0.000565626,0.002034531,0.0007599215,0.0005258743,0.003742047],"category_scores_gemma":[0.000552639,0.0005968912,0.0004054783,0.0004205398,0.0006004153,0.001297366,0.001548272,0.001088416,0.001855761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001207573,"about_ca_system_score_gemma":0.0003189387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001275329,"about_ca_topic_score_gemma":0.003364799,"domain_scores_codex":[0.9994345,0.00003888401,0.00002587745,0.0002530867,0.0001394517,0.0001082065],"domain_scores_gemma":[0.9993599,0.00008459548,0.0001465508,0.0001199737,0.0000776542,0.0002112729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008177907,0.00001090051,0.001073808,0.00001282873,0.000007678173,0.00005067097,0.00003305538,0.0001164209,0.9956316,0.0009564147,0.0001577638,0.001867141],"study_design_scores_gemma":[0.00004651661,0.00008416196,0.08014034,0.0000204205,0.00004657005,0.0006926306,0.0001870672,0.007654755,0.8997235,0.00144223,0.009924896,0.00003687657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9599342,0.003396602,0.02603309,0.0003570993,0.0001082838,0.00002606803,0.0007977612,0.0006158298,0.008731064],"genre_scores_gemma":[0.9906962,0.0004985408,0.003262207,0.00008947495,0.00002725758,0.00002174855,0.0007047778,0.0003481411,0.004351597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003742047,"threshold_uncertainty_score":0.01251835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01849730295370834,"score_gpt":0.2570518893083082,"score_spread":0.2385545863545999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}