{"id":"W2267370236","doi":"10.1016/j.cell.2016.01.004","title":"Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis","year":2016,"lang":"en","type":"article","venue":"Cell","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":224,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"National Institutes of Health; Lawrence J. and Florence A. DeGeorge Charitable Trust; National Heart, Lung, and Blood Institute; Gladstone Institutes; Paul Scherrer Institut; National Center for Research Resources; American Heart Association","keywords":"Biology; Zinc finger; Transcription factor; GATA4; Ectopic expression; Homeobox; Cell biology; Genetics; Gene; Regulation of gene expression; Zinc finger transcription factor; Cell fate determination; Computational biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005815381,0.00009281006,0.00008711776,0.00001883252,0.00005452726,0.00001995542,0.00007891413,0.00007858162,0.00005281871],"category_scores_gemma":[0.00002239688,0.00006885239,0.00005575984,0.0000364668,0.0000884317,0.000005540992,0.0000653599,0.00002874393,0.00002474325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001752994,"about_ca_system_score_gemma":0.00001324759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001125506,"about_ca_topic_score_gemma":0.00002036453,"domain_scores_codex":[0.999345,0.00005331595,0.00008906754,0.0002486988,0.00008459566,0.0001793293],"domain_scores_gemma":[0.9996547,0.00001586772,0.00001659839,0.0001787406,0.00006131335,0.00007284031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004924666,0.00001222173,0.003105796,0.00002353573,0.00001106477,0.000001373167,0.000009660986,2.186231e-7,0.9827538,0.000003126333,0.0003228105,0.01370721],"study_design_scores_gemma":[0.0003359483,0.0001702892,0.04718218,0.00001081873,0.000006512751,0.00001116248,0.00001123881,0.00001848404,0.9410319,0.00003144373,0.01108248,0.0001075879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964386,0.0007637322,0.00221565,0.00009786747,0.00004981978,0.0001418471,0.0001299446,0.00001213861,0.0001504431],"genre_scores_gemma":[0.9982816,0.0001848817,0.00002914183,0.00001220617,0.00005047244,0.00001177655,0.00008147273,0.00001077865,0.001337701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04407638,"threshold_uncertainty_score":0.2807719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01849730295370834,"score_gpt":0.2570518893083082,"score_spread":0.2385545863545999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}