{"id":"W2267529971","doi":"10.1016/j.dnarep.2015.11.008","title":"Disease-associated repeat instability and mismatch repair","year":2015,"lang":"en","type":"review","venue":"DNA repair","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":209,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; University of Toronto; Canada Research Chairs; Hospital for Sick Children","funders":"","keywords":"PMS2; Biology; MSH2; DNA mismatch repair; Trinucleotide repeat expansion; MSH6; Microsatellite instability; Genetics; DNA repair; Tandem repeat; Genome instability; Somatic cell; MLH1; Germline mutation; Mutation; Homologous recombination; DNA; DNA damage; Gene; Microsatellite; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005852997,0.001179414,0.001703841,0.002222631,0.0003053594,0.001346267,0.001110396,0.001487888,0.003774967],"category_scores_gemma":[0.0009404258,0.0003107302,0.000451222,0.002227874,0.0006311878,0.001507185,0.0009463712,0.001773847,0.002116496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006379028,"about_ca_system_score_gemma":0.001279296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001297298,"about_ca_topic_score_gemma":0.003065688,"domain_scores_codex":[0.9998154,0.00002689627,0.00003277385,0.00003605763,0.000066271,0.0000225879],"domain_scores_gemma":[0.9996912,0.0001212447,0.00006028394,0.00001041671,0.00007932666,0.00003742968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001041496,0.0000497062,0.0002175355,0.01578268,0.0001061686,0.0003146063,0.00004482233,0.0004761067,0.001543778,0.002809721,0.05637757,0.9221731],"study_design_scores_gemma":[0.00001892608,0.00004972507,0.0006292198,0.003023943,0.0001695955,0.001612481,0.00005562404,0.0001143315,0.0003768459,0.00280657,0.9911181,0.00002454307],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006631126,0.9986318,0.0001314059,0.000192886,0.0002331416,0.000003531099,0.00002293031,0.000007637735,0.0007103548],"genre_scores_gemma":[0.0004636786,0.9982837,0.0001604539,0.0001847392,0.0002966727,0.000004153517,0.00004560648,0.000001602005,0.0005593339],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003774967,"threshold_uncertainty_score":0.01262856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09436100721801564,"score_gpt":0.3343758903922536,"score_spread":0.240014883174238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}