{"id":"W2267571233","doi":"10.1053/j.gastro.2015.11.050","title":"Hepatitis B Virus–Specific and Global T-Cell Dysfunction in Chronic Hepatitis B","year":2015,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":258,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; National Institute of Allergy and Infectious Diseases; U.S. Department of Veterans Affairs","keywords":"Cytotoxic T cell; Immunology; Hepatitis B virus; FOXP3; Immune system; Medicine; T cell; Antigen; HBeAg; CD8; Hepatitis B; Biology; Virus; In vitro; HBsAg","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001861654,0.0002055799,0.0004418519,0.0001174699,0.00004289131,0.00001361159,0.000066206,0.000112099,0.00008947845],"category_scores_gemma":[0.00005081062,0.0002069183,0.00004839302,0.0001456325,0.000193188,0.00009764332,0.0001231015,0.0002008936,0.0001597669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00089837,"about_ca_system_score_gemma":0.00009095555,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01933757,"about_ca_topic_score_gemma":0.1969617,"domain_scores_codex":[0.9984113,0.0001224207,0.0003470908,0.0003981991,0.0002010115,0.0005200056],"domain_scores_gemma":[0.9993463,0.0000183886,0.00007971827,0.0002412895,0.00009134741,0.0002230033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003720486,0.00009970721,0.9868441,0.00003110366,0.00002812764,0.0001933712,0.0001412898,0.000009174466,0.0007007016,0.00004920344,0.009583177,0.001947958],"study_design_scores_gemma":[0.00418695,0.002808114,0.9835583,0.00004002228,0.00003107566,0.0002565031,0.0000162963,0.0002476061,0.0001207159,0.0001540435,0.008490994,0.00008937708],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942775,0.001452928,0.0007445958,0.00103646,0.000501678,0.0003108439,0.00004419076,0.00006864718,0.001563105],"genre_scores_gemma":[0.993409,0.0045112,0.0006164016,0.0009886572,0.0002409077,0.00005691201,0.00003636401,0.00001935335,0.0001212097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1776241,"threshold_uncertainty_score":0.9871927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02059048951240361,"score_gpt":0.255991397611483,"score_spread":0.2354009080990794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}