{"id":"W2267960813","doi":"10.1161/hyp.60.suppl_1.a449","title":"Abstract 449: Develoment of Endothelin-1 Induced Aneurysms in High-Fat Diet-Fed Apolipoprotein E Knockout Mice Through a Mechanism Involving Oxidative Stress and Inflammatory Cell Infiltration","year":2012,"lang":"en","type":"article","venue":"Hypertension","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Apolipoprotein E; Oxidative stress; Inflammation; Monocyte; Internal medicine; Endocrinology; Knockout mouse; Medicine; Apolipoprotein B; Endothelium; Pathology; Cholesterol; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003374919,0.0009292729,0.0006180937,0.0008070251,0.0003459586,0.0004827648,0.0004198386,0.0008020722,0.004731972],"category_scores_gemma":[0.0001863124,0.0005741672,0.0006803047,0.000254667,0.0004934128,0.0005293016,0.0003881288,0.001574795,0.00118147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003235531,"about_ca_system_score_gemma":0.0002211752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003573084,"about_ca_topic_score_gemma":0.0004798755,"domain_scores_codex":[0.999568,0.00004510581,0.00006102001,0.0001200246,0.0001136867,0.0000921055],"domain_scores_gemma":[0.9994066,0.0000432132,0.0002253501,0.00005148223,0.00005048012,0.0002229736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006591203,0.0001525885,0.0004054539,0.00004169358,0.00001275781,0.0001493331,0.00002449228,0.00001548863,0.9977277,0.00007402237,0.00006278376,0.0006746052],"study_design_scores_gemma":[0.0001917517,0.001740776,0.0254525,0.00003903799,0.00009315406,0.001856357,0.000116477,0.0006874585,0.967282,0.0001204017,0.002400218,0.00001981498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931481,0.0006456915,0.00346862,0.0001810057,0.0001174611,0.00004790305,0.001083786,0.0001477924,0.001159582],"genre_scores_gemma":[0.9690371,0.001437497,0.008306677,0.0002732164,0.00007848143,0.0003074358,0.002533733,0.0001803781,0.01784545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004731972,"threshold_uncertainty_score":0.01583004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02232570255784675,"score_gpt":0.2130843731783091,"score_spread":0.1907586706204624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}