{"id":"W2267979916","doi":"10.1038/ncomms9219","title":"TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; Yamaguchi Endocrine Research Foundation; RIKEN; University of Tokyo; Ministry of Health, Labour and Welfare","keywords":"Epigenetics; Prostate cancer; Androgen receptor; Cancer research; Psychological repression; DNA methylation; Biology; Cancer; P-Chloroamphetamine; Androgen; FOXA1; Chemistry; Endocrinology; Hormone; Receptor; Gene expression; Genetics; Breast cancer; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026284,0.0001338558,0.0001072134,0.00002511817,0.0001769503,0.00004478285,0.0002413661,0.0003328241,0.000001385116],"category_scores_gemma":[0.0001775837,0.0001189188,0.000029219,0.0001616376,0.0001168624,0.00001303709,0.0003378789,0.0002085396,0.000001333796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004335445,"about_ca_system_score_gemma":0.0000907862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005969482,"about_ca_topic_score_gemma":0.0001172746,"domain_scores_codex":[0.999013,0.0001533522,0.0001945349,0.0002845651,0.0001701724,0.0001843621],"domain_scores_gemma":[0.9985828,0.00001786542,0.0001419762,0.0008689327,0.0002271675,0.0001612635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001773511,0.0001763385,0.1558597,0.00001155514,0.00006561262,3.553673e-7,0.0002736715,0.0001231674,0.7709947,0.0003010144,0.009198233,0.06281832],"study_design_scores_gemma":[0.001932292,0.0004685653,0.05954663,0.000063857,0.00008180542,0.000004526394,0.0001741219,0.001802117,0.3930751,0.002975066,0.5393198,0.0005561782],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7299997,0.2675626,0.00007752707,0.00100301,0.00006754744,0.0002897138,0.0001014903,0.00002392549,0.0008745064],"genre_scores_gemma":[0.9746222,0.02043267,0.003437336,0.00006098761,0.00004933121,0.00006619735,0.001155056,0.00001576792,0.0001604027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5301215,"threshold_uncertainty_score":0.484937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0146932686119695,"score_gpt":0.335475326086438,"score_spread":0.3207820574744685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}