{"id":"W2267979916","doi":"10.1038/ncomms9219","title":"TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; Yamaguchi Endocrine Research Foundation; RIKEN; University of Tokyo; Ministry of Health, Labour and Welfare","keywords":"Epigenetics; Prostate cancer; Androgen receptor; Cancer research; Psychological repression; DNA methylation; Biology; Cancer; P-Chloroamphetamine; Androgen; FOXA1; Chemistry; Endocrinology; Hormone; Receptor; Gene expression; Genetics; Breast cancer; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001025779,0.0001995963,0.0001458957,0.0001579344,0.0001281662,0.0003330596,0.0001693462,0.000196458,0.002428516],"category_scores_gemma":[0.0001110238,0.0001017354,0.0001617089,0.000136898,0.0001566872,0.0001688471,0.0002560338,0.0003218005,0.0003378604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000315362,"about_ca_system_score_gemma":0.0001979753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009265539,"about_ca_topic_score_gemma":0.002372735,"domain_scores_codex":[0.999923,0.000009005967,0.000003827708,0.00002108599,0.00002751758,0.00001554935],"domain_scores_gemma":[0.9999387,0.000006911107,0.00002153546,0.000006358212,0.00001107276,0.00001529127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001709543,0.00002592735,0.001643438,0.00007294404,0.00001775018,0.00008737998,0.00002731828,0.0001783351,0.9865803,0.0006275907,0.000381356,0.01018656],"study_design_scores_gemma":[0.0000278528,0.0003751281,0.04902107,0.00001882764,0.00003826719,0.0005439692,0.00006914861,0.002406571,0.922766,0.0005728706,0.02414273,0.00001760243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9517552,0.0240279,0.01053398,0.0009218947,0.000228063,0.00004247922,0.001014735,0.0005168218,0.01095905],"genre_scores_gemma":[0.9866043,0.003344692,0.0009927579,0.0001055419,0.0000332846,0.00001717439,0.0004234018,0.0000231506,0.008455754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002428516,"threshold_uncertainty_score":0.008124173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0146932686119695,"score_gpt":0.335475326086438,"score_spread":0.3207820574744685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}