{"id":"W2268001801","doi":"10.1038/ncomms10494","title":"Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":189,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; Université Laval; Institut National d'Optique","funders":"FP7 Ideas: European Research Council; National Center for Research Resources; National Heart, Lung, and Blood Institute; National Institute on Aging; Medical Research Council; U.S. Public Health Service; National Institutes of Health; Provincia autonoma di Bolzano - Alto Adige; European Regional Development Fund; Dutch Arthritis Association; King's College London; Academy of Finland; Terveyden ja hyvinvoinnin laitos; H. Lundbeck A/S; National Institute of Diabetes and Digestive and Kidney Diseases; Knut och Alice Wallenbergs Stiftelse; Turun Yliopistollinen Keskussairaala; Amgen; Chinese Society of Clinical Oncology; Novo Nordisk Fonden; Orionin Tutkimussäätiö; Emil Aaltosen Säätiö; Augustinus Fonden; National Human Genome Research Institute; Danmarks Frie Forskningsfond; National Institute for Health and Care Research; Lastentautien Tutkimussäätiö; Diabetesforeningen; Vetenskapsrådet; Donald W. Reynolds Foundation; Hersenstichting; GlaxoSmithKline; Signe ja Ane Gyllenbergin Säätiö; Juho Vainion Säätiö; Paavo Nurmen Säätiö; Li Ka Shing Foundation; Centre for Medical Systems Biology; Novo Nordisk; Hjärt-Lungfonden; National Cancer Institute; Lundbeckfonden; Suomen Kulttuurirahasto; Stiftelsen för Strategisk Forskning; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Universiteit Leiden; Bristol-Myers Squibb; Umeå Universitet; National Institute on Minority Health and Health Disparities; European Commission; Canadian Institutes of Health Research; Diabetes UK; British Heart Foundation; Bundesministerium für Bildung und Forschung; Tampereen Tuberkuloosisäätiö; Kela; Ministero della Salute; Pfizer; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; National Center for Advancing Translational Sciences; Hjerteforeningen; National Science Foundation","keywords":"Genome; Leptin; Biology; Genetics; Meta-analysis; Computational biology; Gene; Medicine; Obesity; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004624765,0.001619936,0.003201182,0.001981014,0.0006681255,0.002528979,0.001340769,0.001496157,0.002599776],"category_scores_gemma":[0.007900524,0.0007311818,0.009295194,0.00438676,0.000526146,0.0005810219,0.00120783,0.001441308,0.0002471278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004422859,"about_ca_system_score_gemma":0.0007733296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005945267,"about_ca_topic_score_gemma":0.007540119,"domain_scores_codex":[0.9958717,0.001686236,0.0004000725,0.001353053,0.0003338086,0.0003551033],"domain_scores_gemma":[0.993705,0.00402686,0.0008434344,0.0008100446,0.0002598237,0.0003548894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.004522149,0.00006002812,0.7047033,0.001651012,0.2590365,0.001506045,0.0001471892,0.002614976,0.005454032,0.0005604997,0.001927456,0.01781678],"study_design_scores_gemma":[0.0005846057,0.0005598494,0.7481616,0.0003329023,0.2357167,0.001532839,0.0002365446,0.005795945,0.00136778,0.002045215,0.003600974,0.0000650891],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8616053,0.1163974,0.01082582,0.002483727,0.0004242628,0.00004773562,0.00572496,0.0005072511,0.001983483],"genre_scores_gemma":[0.9883604,0.007572678,0.001887521,0.0003190094,0.000121003,0.00003403423,0.001363016,0.00007293079,0.0002692908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005945267,"threshold_uncertainty_score":0.02445841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1210595452896893,"score_gpt":0.3318635427887936,"score_spread":0.2108039974991043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}