{"id":"W2268001801","doi":"10.1038/ncomms10494","title":"Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":189,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; Université Laval; Institut National d'Optique","funders":"FP7 Ideas: European Research Council; National Center for Research Resources; National Heart, Lung, and Blood Institute; National Institute on Aging; Medical Research Council; U.S. Public Health Service; National Institutes of Health; Provincia autonoma di Bolzano - Alto Adige; European Regional Development Fund; Dutch Arthritis Association; King's College London; Academy of Finland; Terveyden ja hyvinvoinnin laitos; H. Lundbeck A/S; National Institute of Diabetes and Digestive and Kidney Diseases; Knut och Alice Wallenbergs Stiftelse; Turun Yliopistollinen Keskussairaala; Amgen; Chinese Society of Clinical Oncology; Novo Nordisk Fonden; Orionin Tutkimussäätiö; Emil Aaltosen Säätiö; Augustinus Fonden; National Human Genome Research Institute; Danmarks Frie Forskningsfond; National Institute for Health and Care Research; Lastentautien Tutkimussäätiö; Diabetesforeningen; Vetenskapsrådet; Donald W. Reynolds Foundation; Hersenstichting; GlaxoSmithKline; Signe ja Ane Gyllenbergin Säätiö; Juho Vainion Säätiö; Paavo Nurmen Säätiö; Li Ka Shing Foundation; Centre for Medical Systems Biology; Novo Nordisk; Hjärt-Lungfonden; National Cancer Institute; Lundbeckfonden; Suomen Kulttuurirahasto; Stiftelsen för Strategisk Forskning; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Universiteit Leiden; Bristol-Myers Squibb; Umeå Universitet; National Institute on Minority Health and Health Disparities; European Commission; Canadian Institutes of Health Research; Diabetes UK; British Heart Foundation; Bundesministerium für Bildung und Forschung; Tampereen Tuberkuloosisäätiö; Kela; Ministero della Salute; Pfizer; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; National Center for Advancing Translational Sciences; Hjerteforeningen; National Science Foundation","keywords":"Genome; Leptin; Biology; Genetics; Meta-analysis; Computational biology; Gene; Medicine; Obesity; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004554272,0.0001852578,0.0004145984,0.0002795253,0.0006127188,0.00008342687,0.001460211,0.0002115499,0.0003284223],"category_scores_gemma":[0.001606105,0.0001313145,0.0006416152,0.001366669,0.0002103283,0.0004174307,0.0004458732,0.0004706108,0.0001071692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001254124,"about_ca_system_score_gemma":0.00006860989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000257016,"about_ca_topic_score_gemma":0.0002473313,"domain_scores_codex":[0.9982938,0.0002375046,0.0004010642,0.0004060845,0.0004035035,0.000258013],"domain_scores_gemma":[0.9951553,0.001794348,0.0002958612,0.002482859,0.0001730554,0.00009855131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000006200022,0.0001473432,0.01902522,0.000007047229,0.005559545,0.000002027753,0.0004465491,0.002313798,0.9473578,0.0245154,0.0001872931,0.0004318143],"study_design_scores_gemma":[0.001107584,0.0000402149,0.6096268,0.00001788995,0.03739154,0.00001889436,0.0001764666,0.001481567,0.194106,0.002673352,0.1521406,0.001219143],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8965476,0.002640228,0.03801169,0.03724748,0.0001432978,0.0007908361,0.0003880335,0.000498783,0.02373208],"genre_scores_gemma":[0.9915402,0.00006631864,0.005346107,0.002171109,0.00002386918,0.00002157892,0.00001503079,0.00001802046,0.0007977692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7532518,"threshold_uncertainty_score":0.5354848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1210595452896893,"score_gpt":0.3318635427887936,"score_spread":0.2108039974991043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}