{"id":"W2268068174","doi":"","title":"Bivalent binding properties of epidermal growth factor receptor targeted monoclonal antibodies: Factors contributing to differences in observed clinical profiles.","year":2008,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Nimotuzumab; Cetuximab; Monoclonal antibody; Epidermal growth factor receptor; Antibody; Chemistry; Panitumumab; Cancer research; Cell culture; Molecular biology; Antibody-dependent cell-mediated cytotoxicity; A431 cells; Cell growth; Monoclonal; Cell; Receptor; Immunology; Cell cycle; Medicine; Biology; Biochemistry; Molecular medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001714019,0.0002978582,0.000493942,0.0005927975,0.0002188309,0.0007739603,0.0004134272,0.0005190137,0.002257934],"category_scores_gemma":[0.002602381,0.0002038131,0.0002028977,0.0004738024,0.0002954505,0.0004153524,0.0003129957,0.0006293562,0.0006950079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004205782,"about_ca_system_score_gemma":0.0001694484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003298252,"about_ca_topic_score_gemma":0.0003800472,"domain_scores_codex":[0.9986338,0.0003810841,0.0001117563,0.0002364955,0.000501471,0.0001353556],"domain_scores_gemma":[0.9980647,0.0008914909,0.000478917,0.0001403719,0.0002433574,0.0001812391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001447005,0.0003647936,0.02486368,0.0004086293,0.0001562717,0.0003758096,0.0001398071,0.000851305,0.8721248,0.0006629073,0.0008793325,0.09772572],"study_design_scores_gemma":[0.0002870647,0.008117986,0.2571481,0.00009679553,0.0004777864,0.01153778,0.0002197063,0.008269947,0.684993,0.001475272,0.02730174,0.00007478894],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9563971,0.02620897,0.009360177,0.0005046208,0.00006676517,0.0002082665,0.0004916477,0.0001490834,0.006613242],"genre_scores_gemma":[0.9944854,0.001723285,0.001896536,0.0002505826,0.00003245792,0.00008408065,0.0005282117,0.00002863899,0.0009706678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002257934,"threshold_uncertainty_score":0.009064734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6654379160890438,"score_gpt":0.5353623484376453,"score_spread":0.1300755676513985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}