{"id":"W2268106067","doi":"10.1182/blood.v124.21.4816.4816","title":"Design, Optimization, and Pre-Clinical Evaluation of Direct, Mechanism-Based STAT3 Inhibitors for Treating Myeloid Disorders","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; York University","funders":"","keywords":"Myeloid leukemia; Cancer research; Chemistry; Myeloid; Biology; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005122176,0.0005034553,0.0005423359,0.0004145018,0.0001551222,0.0006887127,0.0005980807,0.000346607,0.002440346],"category_scores_gemma":[0.0002211518,0.0002613233,0.0005094643,0.0002287264,0.0002357779,0.0003041009,0.0003129101,0.0009277571,0.00054969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006247875,"about_ca_system_score_gemma":0.0005743527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006388635,"about_ca_topic_score_gemma":0.00204687,"domain_scores_codex":[0.9998376,0.00002714093,0.00001062693,0.00002611114,0.00006207824,0.00003643827],"domain_scores_gemma":[0.9999136,0.000008913175,0.00002768845,0.000005302329,0.00002063001,0.00002397747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003348421,0.00253636,0.002295515,0.001107486,0.0002585555,0.0002920652,0.00007184607,0.01992916,0.8621399,0.001897279,0.002258218,0.1038651],"study_design_scores_gemma":[0.004317141,0.04098553,0.009317291,0.0002042814,0.0008215997,0.001390524,0.0001555814,0.04021716,0.8455355,0.001255009,0.05569476,0.0001056014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9412806,0.02698699,0.01902113,0.0008499158,0.0001886757,0.001199377,0.002088504,0.0003251885,0.00805966],"genre_scores_gemma":[0.9778097,0.008523333,0.009307222,0.0002751792,0.00002281737,0.0002791639,0.001162152,0.00003293512,0.00258741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002440346,"threshold_uncertainty_score":0.00816375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02850985279357675,"score_gpt":0.3164154528712008,"score_spread":0.287905600077624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}