{"id":"W2268167744","doi":"10.14785/lymphosign-2015-0014","title":"Heterozygous mutations in RelB can be associated with immune dysregulation and lymphoma","year":2016,"lang":"en","type":"article","venue":"LymphoSign Journal","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto; Janeway Children's Health and Rehabilitation Centre; Memorial University of Newfoundland","funders":"Ontario Ministry of Research and Innovation; Hospital for Sick Children; Genome Canada; Ontario Genomics; Ontario Genomics Institute; Immunodeficiency Canada; Jeffrey Modell Foundation","keywords":"RELB; Immune system; Immunology; Haploinsufficiency; Lymphoma; Immune dysregulation; Biology; Immunodeficiency; Antigen; Cancer research; Medicine; Transcription factor; Genetics; NFKB1; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000284691,0.0001401642,0.0001378909,0.00008667179,0.0001242833,0.00004421018,0.0001040367,0.0001226457,0.00001196645],"category_scores_gemma":[0.0001220974,0.00009906133,0.00004122952,0.00010355,0.00009164127,0.000009874967,0.0000302331,0.00004227931,0.00000122737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001274168,"about_ca_system_score_gemma":0.0001807635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002888118,"about_ca_topic_score_gemma":0.0001473946,"domain_scores_codex":[0.9990268,0.00009732544,0.0002548942,0.0002085601,0.0001584157,0.0002540296],"domain_scores_gemma":[0.9994403,0.00003381757,0.0001760191,0.0001524149,0.00009888209,0.00009856826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001217177,0.00006560352,0.01508718,0.000002430731,0.00006764627,0.00004972477,0.0002390518,0.00006654918,0.9751313,0.00003793723,0.0001603231,0.00897049],"study_design_scores_gemma":[0.01318994,0.001717472,0.2131038,0.0004853606,0.00007743231,0.00233697,0.0002526785,0.0002013059,0.7653384,0.001432666,0.001137152,0.0007268652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960697,0.000359116,0.002775289,0.0005113559,0.00007957216,0.00009039587,0.00001777804,0.00001133775,0.00008545937],"genre_scores_gemma":[0.9990323,0.00007467171,0.0003873201,0.0001448279,0.00008946924,0.00000895775,0.00003017145,0.00002745487,0.0002048472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.209793,"threshold_uncertainty_score":0.4039603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008958729128634263,"score_gpt":0.2104445306669108,"score_spread":0.2014858015382766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}