{"id":"W2268301683","doi":"10.1128/mcb.00344-15","title":"Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin Pathway","year":2015,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"IRF3; Biology; GSK-3; Innate immune system; RIG-I; Interferon regulatory factors; Interferon; Cell biology; Pattern recognition receptor; Transcription factor; MDA5; Phosphorylation; Molecular biology; Immune system; Virology; Immunology; Biochemistry; Gene; RNA; RNA interference","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001701301,0.0003995742,0.0002071526,0.0002694262,0.00009949018,0.0003580731,0.0001958195,0.0002241835,0.0009507001],"category_scores_gemma":[0.00009414742,0.000168324,0.0003603339,0.0001296765,0.0002781057,0.0002390091,0.0002297802,0.0005203339,0.0003288146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002415737,"about_ca_system_score_gemma":0.0002359603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002713843,"about_ca_topic_score_gemma":0.0006202855,"domain_scores_codex":[0.9998796,0.00001835131,0.00001845887,0.00002595864,0.00002856265,0.00002894377],"domain_scores_gemma":[0.9999374,0.000006993103,0.00002318002,0.000008946431,0.000005449944,0.00001802064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005793618,0.000006605854,0.0001071334,0.00001860888,0.000003080189,0.00002823848,0.000004131631,0.00004061767,0.9992449,0.00007515259,0.00001210499,0.0004014663],"study_design_scores_gemma":[0.00004478012,0.0001079023,0.003785739,0.000008742527,0.00002475074,0.0002168044,0.00002246377,0.0009814319,0.9928664,0.00008288385,0.001851859,0.000006268552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904168,0.002292433,0.003790555,0.0001748085,0.00006500788,0.00004917077,0.0004971934,0.0001412282,0.002572761],"genre_scores_gemma":[0.9935265,0.001201685,0.003069756,0.00008778565,0.000009385723,0.00004543596,0.000339297,0.00002395705,0.001696313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009507001,"threshold_uncertainty_score":0.003180385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01142324711448068,"score_gpt":0.2199912342986111,"score_spread":0.2085679871841304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}