{"id":"W2268503251","doi":"10.1021/acs.biochem.5b01178","title":"The Dynamic Landscape of the Full-Length HIV-1 Transactivator of Transcription","year":2016,"lang":"en","type":"article","venue":"Biochemistry","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Transactivation; Human immunodeficiency virus (HIV); Transcription (linguistics); Transcription factor; Computational biology; Biology; Genetics; Virology; Gene; Philosophy; Linguistics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007862609,0.0001109775,0.0001544221,0.0001820777,0.0002120331,0.0003738747,0.0002562362,0.0002281916,0.0009007136],"category_scores_gemma":[0.0002301029,0.0001374937,0.0001080597,0.0001504624,0.0002182223,0.0003816299,0.0001591966,0.0002597334,0.0001878628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003460881,"about_ca_system_score_gemma":0.0001939208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008699922,"about_ca_topic_score_gemma":0.0008924778,"domain_scores_codex":[0.9999548,0.000004564687,0.000001219617,0.00001678146,0.00001168237,0.0000110097],"domain_scores_gemma":[0.9999244,0.00002539717,0.00001486535,0.000004479166,0.0000131798,0.00001762048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002197328,0.00005937317,0.006400472,0.00009628746,0.0000516923,0.0002225128,0.0001475619,0.008951895,0.9680568,0.002411371,0.0004450309,0.01293731],"study_design_scores_gemma":[0.00008799019,0.0007098779,0.206093,0.00005261575,0.0001367858,0.001084121,0.0006434244,0.3801144,0.3860539,0.008936021,0.01593328,0.0001546057],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995246,0.0008110872,0.002439348,0.00006883644,0.000004173013,0.000004757675,0.0002069133,0.00005099031,0.001168083],"genre_scores_gemma":[0.9975287,0.0004725674,0.001153084,0.0000290566,0.00000513745,0.00001303954,0.0003102065,0.00001753179,0.0004708229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009007136,"threshold_uncertainty_score":0.003013194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005288138596204145,"score_gpt":0.2148862259476452,"score_spread":0.2095980873514411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}