{"id":"W2268946907","doi":"10.1038/srep10730","title":"SUMO1 Affects Synaptic Function, Spine Density and Memory","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Occupational Cancer Research Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; Japan Society for the Promotion of Science; Canadian Institutes of Health Research; National Institutes of Health; Alzheimer's Society","keywords":"SUMO protein; Neurodegeneration; Biology; Neuroscience; Neurotransmission; Dendritic spine; Synapse; Cell biology; Transgene; Ubiquitin; Biochemistry; Medicine; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001009204,0.0004280111,0.0002119266,0.0003210461,0.0001542811,0.0002564312,0.0002278816,0.0003248208,0.001124575],"category_scores_gemma":[0.00009149723,0.0001450696,0.0002117028,0.0001472497,0.0002540299,0.000205126,0.0001879027,0.0004902855,0.0001896605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002066487,"about_ca_system_score_gemma":0.0001369142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000745685,"about_ca_topic_score_gemma":0.0009970189,"domain_scores_codex":[0.9999231,0.000007698835,0.000008349105,0.00001884439,0.00002033451,0.0000215773],"domain_scores_gemma":[0.9998993,0.000006945084,0.00003753196,0.000008347695,0.000009506349,0.00003829053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000202933,0.00003598358,0.0008138701,0.00001383185,0.000007845497,0.00006386565,0.000009414058,0.00003471186,0.9977288,0.00003216129,0.00002094199,0.001035733],"study_design_scores_gemma":[0.00001237945,0.0005349685,0.02847679,0.000004836426,0.00004637865,0.00029886,0.00003666698,0.0004569329,0.9693902,0.00007931406,0.0006581001,0.000004700509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984856,0.0005200428,0.0004068361,0.00003640993,0.000009386001,0.000003771379,0.000176213,0.00002804283,0.0003337085],"genre_scores_gemma":[0.9963287,0.0007172303,0.000401928,0.00001834131,0.000003606961,0.000007695964,0.000218974,0.000008735496,0.002294806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001124575,"threshold_uncertainty_score":0.003762007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01570975007630896,"score_gpt":0.232478107574498,"score_spread":0.2167683574981891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}