{"id":"W2268946907","doi":"10.1038/srep10730","title":"SUMO1 Affects Synaptic Function, Spine Density and Memory","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Occupational Cancer Research Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; Japan Society for the Promotion of Science; Canadian Institutes of Health Research; National Institutes of Health; Alzheimer's Society","keywords":"SUMO protein; Neurodegeneration; Biology; Neuroscience; Neurotransmission; Dendritic spine; Synapse; Cell biology; Transgene; Ubiquitin; Biochemistry; Medicine; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001113153,0.0001053983,0.0001026139,0.00004338093,0.0001429465,0.00009263354,0.00005445634,0.00008452043,0.0000162497],"category_scores_gemma":[0.0002660818,0.00009523542,0.00003891478,0.0001059745,0.0001870764,0.000005965979,0.0001189726,0.00005367995,0.00001588481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009956612,"about_ca_system_score_gemma":0.0001326097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000075209,"about_ca_topic_score_gemma":0.00002399181,"domain_scores_codex":[0.9988669,0.00004548643,0.0001486087,0.0005437125,0.0001991974,0.0001961271],"domain_scores_gemma":[0.9990324,0.000002832827,0.00009769356,0.0005208644,0.0001491408,0.0001970084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002719725,0.0000399912,0.007499826,0.00002957617,0.00003367973,0.0001494177,0.00007729145,0.00001227862,0.9539186,0.00004641784,0.03581686,0.002348843],"study_design_scores_gemma":[0.0002629051,0.000245443,0.003295098,0.00001638551,0.00002889838,0.0008378368,0.00009022892,0.00003326747,0.88178,0.002348462,0.1108255,0.0002359919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925023,0.001029689,0.0003910208,0.00006345419,0.003025775,0.0001949981,7.384151e-7,0.00002596632,0.002765998],"genre_scores_gemma":[0.9950829,0.000004854167,0.0003090689,0.0000786228,0.0001656841,0.00001150938,0.00007323458,0.00001054399,0.004263605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07500861,"threshold_uncertainty_score":0.3883588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01570975007630896,"score_gpt":0.232478107574498,"score_spread":0.2167683574981891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}