{"id":"W2269021429","doi":"10.1023/a:1011183905848","title":"Phase I study of the matrix metalloproteinase inhibitor, BAY 12-9566","year":2001,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Bayer Canada","keywords":"Medicine; Pyridinoline; Deoxypyridinoline; Vascular endothelial growth factor; Internal medicine; Pharmacokinetics; Gastroenterology; Matrix metalloproteinase inhibitor; Matrix metalloproteinase; VEGF receptors; Alkaline phosphatase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001135258,0.002242227,0.002475529,0.0006376326,0.0004929312,0.001267415,0.001036538,0.001462213,0.003788577],"category_scores_gemma":[0.0007980288,0.0008238091,0.001287098,0.000601487,0.001040152,0.0008085107,0.0002640563,0.004293368,0.001186502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008438283,"about_ca_system_score_gemma":0.002087219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001390214,"about_ca_topic_score_gemma":0.002152323,"domain_scores_codex":[0.9996395,0.0001384931,0.00001112543,0.00005160794,0.00003661541,0.0001227328],"domain_scores_gemma":[0.9994866,0.00009925484,0.0001017352,0.00005650972,0.00003141555,0.0002244951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7400474,0.1066867,0.002152149,0.0007300369,0.0009897895,0.000194917,0.0002552603,0.003751339,0.05507642,0.0008939951,0.005156675,0.08406538],"study_design_scores_gemma":[0.3794322,0.6040875,0.003306346,0.00002566874,0.0004279724,0.0002141092,0.00006566243,0.001118034,0.008404254,0.0002556383,0.002633759,0.00002878892],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881884,0.004349118,0.001409124,0.0006162662,0.000366658,0.001630339,0.0008752087,0.0001935532,0.002371327],"genre_scores_gemma":[0.9803438,0.005004348,0.00201055,0.0007882389,0.0003549048,0.002072725,0.001683049,0.0000574704,0.007684891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003788577,"threshold_uncertainty_score":0.01267409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04761669532929767,"score_gpt":0.3661026461916042,"score_spread":0.3184859508623065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}