{"id":"W2269299082","doi":"10.1074/jbc.m115.678433","title":"Deletion of MLIP (Muscle-enriched A-type Lamin-interacting Protein) Leads to Cardiac Hyperactivation of Akt/Mammalian Target of Rapamycin (mTOR) and Impaired Cardiac Adaptation","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institutes of Health; Canadian Institutes of Health Research; University of Ottawa Heart Institute Foundation; University of Ottawa; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada","keywords":"PI3K/AKT/mTOR pathway; Protein kinase B; Biology; Cardiac muscle; Cardiac function curve; Lamin; Mechanistic target of rapamycin; Homeostasis; Cell biology; Internal medicine; Endocrinology; Heart failure; Signal transduction; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001737658,0.000886504,0.0002743053,0.0007986801,0.0003276108,0.0004039707,0.0005491017,0.0006923649,0.002395158],"category_scores_gemma":[0.0001395995,0.0003698949,0.0005576257,0.0002388091,0.0004662521,0.0003142393,0.0006333269,0.001067273,0.0008044733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003451802,"about_ca_system_score_gemma":0.0002249772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004631494,"about_ca_topic_score_gemma":0.0006069943,"domain_scores_codex":[0.9997249,0.00003028803,0.00004964558,0.00008438944,0.00006292347,0.00004780757],"domain_scores_gemma":[0.999525,0.00004431297,0.0002333828,0.00002878779,0.00001541417,0.0001532011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001209172,0.00002192653,0.0002262317,0.00003357532,0.00001139077,0.0001361584,0.00000797731,0.00005078922,0.9987178,0.00007491129,0.00003240386,0.000565968],"study_design_scores_gemma":[0.00005890107,0.0003989846,0.0172129,0.00002613652,0.00008073419,0.00166662,0.00007699685,0.001726478,0.9745205,0.0001634488,0.004049673,0.00001859809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879687,0.001473538,0.007107318,0.0002312923,0.00007176493,0.00004902566,0.001431138,0.0003792642,0.001288038],"genre_scores_gemma":[0.9879633,0.0009825617,0.004961569,0.0001422623,0.00003632015,0.00008375935,0.002051734,0.0001135668,0.003664955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002395158,"threshold_uncertainty_score":0.008012593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0230529445916322,"score_gpt":0.2467986357339876,"score_spread":0.2237456911423554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}