{"id":"W2269600757","doi":"10.1038/ncomms7760","title":"Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":325,"is_retracted":false,"has_abstract":true,"ca_institutions":"St Joseph's Health Care; Sunnybrook Health Science Centre; McGill University; Jewish General Hospital","funders":"National Institute on Aging; National Health and Medical Research Council; Australian Research Council; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, San Diego; National Institutes of Health; Bristol-Myers Squibb; Yulgilbar Foundation; Genentech; IXICO; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Australian Government; F. Hoffmann-La Roche; Synarc; University of Southern California; Medpace; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Alzheimer's Disease Neuroimaging Initiative; National Center for Advancing Translational Sciences; Medical Research Council; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Apolipoprotein E; Ferritin; Alzheimer's Disease Neuroimaging Initiative; Cerebrospinal fluid; Alzheimer's disease; Medicine; Internal medicine; Disease; Cohort; Neuroimaging; Oncology; Endocrinology; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004755105,0.0001217857,0.0001890506,0.00009907137,0.0001610058,0.00004543563,0.000632015,0.0001818514,0.0000139045],"category_scores_gemma":[0.0005734166,0.0000801446,0.00004674862,0.0003537526,0.0002239757,0.00009669812,0.0002483668,0.00106256,0.00001368119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004473966,"about_ca_system_score_gemma":0.0001424418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008344391,"about_ca_topic_score_gemma":0.000239587,"domain_scores_codex":[0.9988067,0.0002384139,0.0002001214,0.0001705913,0.0003805849,0.0002036612],"domain_scores_gemma":[0.9977899,0.0002038451,0.00004540394,0.001551863,0.0001866453,0.0002223226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002023777,0.0009056251,0.7846975,0.00003301734,0.000175371,0.00003181604,0.0008896932,0.000001379677,0.0006044792,0.002184502,0.2075581,0.002716084],"study_design_scores_gemma":[0.001267748,0.00007769997,0.9471087,0.00006867926,0.00009892995,0.00001884195,0.0004962395,0.00062606,0.00004191225,0.0001719286,0.04993115,0.00009208688],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7629992,0.08372617,0.000005462458,0.1468524,0.0000706146,0.001189525,0.0003054926,0.00009684311,0.004754266],"genre_scores_gemma":[0.9968399,0.000457524,0.0002836531,0.001575542,0.00002523694,0.00005945198,0.0002937297,0.00001491242,0.0004500763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2338406,"threshold_uncertainty_score":0.4616355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1024287989079321,"score_gpt":0.3883938733451648,"score_spread":0.2859650744372327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}