{"id":"W2269600757","doi":"10.1038/ncomms7760","title":"Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":325,"is_retracted":false,"has_abstract":true,"ca_institutions":"St Joseph's Health Care; Sunnybrook Health Science Centre; McGill University; Jewish General Hospital","funders":"National Institute on Aging; National Health and Medical Research Council; Australian Research Council; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, San Diego; National Institutes of Health; Bristol-Myers Squibb; Yulgilbar Foundation; Genentech; IXICO; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Australian Government; F. Hoffmann-La Roche; Synarc; University of Southern California; Medpace; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Alzheimer's Disease Neuroimaging Initiative; National Center for Advancing Translational Sciences; Medical Research Council; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Apolipoprotein E; Ferritin; Alzheimer's Disease Neuroimaging Initiative; Cerebrospinal fluid; Alzheimer's disease; Medicine; Internal medicine; Disease; Cohort; Neuroimaging; Oncology; Endocrinology; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006682612,0.0002995481,0.0002215302,0.0006715683,0.0002371869,0.0005286706,0.0001807749,0.0004056066,0.0007894875],"category_scores_gemma":[0.002306889,0.0001861537,0.0002130784,0.0003766842,0.0003363852,0.0002131368,0.0002398133,0.0003595724,0.0002224284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002300312,"about_ca_system_score_gemma":0.0001582063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004319265,"about_ca_topic_score_gemma":0.003731178,"domain_scores_codex":[0.9998112,0.00004774539,0.00001954368,0.00004090697,0.00004191558,0.00003869119],"domain_scores_gemma":[0.9988348,0.0001975346,0.0006056612,0.00008180178,0.000129557,0.0001506273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009977958,0.00006346314,0.9929633,0.000005465043,0.00005703673,0.0001316047,0.0001114952,0.00005648622,0.002997775,0.00002293193,0.00009008876,0.002502585],"study_design_scores_gemma":[0.000006704644,0.00007381968,0.9991633,0.000002422488,0.00001592285,0.000158336,0.00004312455,0.0001239835,0.0002985278,0.00006195714,0.00005003971,0.000001995826],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995753,0.00009915978,0.00004248413,0.00001903998,0.00000196612,0.000001225664,0.00004516615,0.00000263072,0.0002129009],"genre_scores_gemma":[0.9996616,0.00004264717,0.00004740068,0.000007791331,0.000003039735,0.000001362616,0.00008043435,0.000001117485,0.0001545183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004319265,"threshold_uncertainty_score":0.008588195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1024287989079321,"score_gpt":0.3883938733451648,"score_spread":0.2859650744372327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}