{"id":"W2269993080","doi":"10.1093/toxsci/kfv107","title":"NADPH Oxidase-Mediated Superoxide Production by Intermediary Bacterial Metabolites of Dibenzofuran: A Potential Cause for Trans-Mitochondrial Membrane Potential (ΔΨm) Collapse in Human Hepatoma Cells","year":2015,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Dibenzofuran; Chemistry; Superoxide; Reactive oxygen species; Oxidative stress; Toxicity; Mitochondrion; Biochemistry; Photobacterium phosphoreum; NADPH oxidase; Catalase; Oxidase test; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001323899,0.0003932772,0.0002318442,0.0001864576,0.0001479228,0.0001644056,0.0001573935,0.0002824805,0.0007650903],"category_scores_gemma":[0.0001087511,0.0001494911,0.0002812736,0.0002449422,0.0001279356,0.0002140838,0.0001728067,0.0004848114,0.0002161336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002294982,"about_ca_system_score_gemma":0.0001224268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008313341,"about_ca_topic_score_gemma":0.0009320199,"domain_scores_codex":[0.999842,0.00002810619,0.00001443007,0.00003248414,0.0000471071,0.00003585702],"domain_scores_gemma":[0.9999089,0.00000887356,0.00003425354,0.000009128211,0.00002286195,0.00001592372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000159683,0.00002466194,0.0007671654,0.00005100024,0.00000730906,0.0001490672,0.00002803774,0.00002387745,0.9979128,0.00003279482,0.00003526957,0.0008083701],"study_design_scores_gemma":[0.000009794406,0.0003765764,0.009790572,0.000006084954,0.00002082165,0.0004124759,0.00004873962,0.0003264993,0.9880744,0.00004547089,0.0008843324,0.000004232466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870952,0.005805503,0.005303333,0.0002206675,0.00006157151,0.00004158209,0.0005232495,0.00006431658,0.0008847077],"genre_scores_gemma":[0.9958,0.001143563,0.001471812,0.00004679163,0.00001060001,0.00002521327,0.0005440373,0.000005010718,0.0009530734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008313341,"threshold_uncertainty_score":0.002559483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1102166808656185,"score_gpt":0.3970106824841867,"score_spread":0.2867940016185682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}