{"id":"W2269993080","doi":"10.1093/toxsci/kfv107","title":"NADPH Oxidase-Mediated Superoxide Production by Intermediary Bacterial Metabolites of Dibenzofuran: A Potential Cause for Trans-Mitochondrial Membrane Potential (ΔΨm) Collapse in Human Hepatoma Cells","year":2015,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Dibenzofuran; Chemistry; Superoxide; Reactive oxygen species; Oxidative stress; Toxicity; Mitochondrion; Biochemistry; Photobacterium phosphoreum; NADPH oxidase; Catalase; Oxidase test; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002399772,0.000453886,0.0008483173,0.0002965423,0.0003661094,0.00007659111,0.0008628499,0.0005905307,0.0009290255],"category_scores_gemma":[0.0005078413,0.0003697597,0.0002570834,0.0007765657,0.001606748,0.0003573132,0.000156717,0.0005529053,0.00001320501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008705448,"about_ca_system_score_gemma":0.0003134284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000860008,"about_ca_topic_score_gemma":0.00009357387,"domain_scores_codex":[0.9952492,0.001089483,0.001073107,0.0009292893,0.000627117,0.001031856],"domain_scores_gemma":[0.9981897,0.0003880975,0.0003282239,0.00020757,0.0002377569,0.0006486346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001833414,0.001385576,0.0005020746,0.00003612778,0.00009086745,0.0000407687,0.0005519812,0.001016511,0.9888772,0.0001146032,0.004475674,0.001075138],"study_design_scores_gemma":[0.006499664,0.0009340372,0.0005862436,0.00001306154,0.000266824,0.00002236357,0.0002506729,0.002612893,0.9695485,0.0007045284,0.01808339,0.0004777869],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882416,0.0007833584,0.0001502049,0.000982283,0.007147621,0.001684295,0.0007151237,0.0000915975,0.0002039657],"genre_scores_gemma":[0.9967125,0.0003031484,0.0006723363,0.0004679375,0.001228013,0.0002577917,0.0001432956,0.00002494701,0.0001900362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01932873,"threshold_uncertainty_score":0.9999843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1102166808656185,"score_gpt":0.3970106824841867,"score_spread":0.2867940016185682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}