{"id":"W2270545352","doi":"10.1039/c5nr07436c","title":"Multifunctional nanoparticle–protein conjugates with controllable bioactivity and pH responsiveness","year":2016,"lang":"en","type":"article","venue":"Nanoscale","topic":"Polymer Surface Interaction Studies","field":"Materials Science","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Conjugate; Nanoparticle; Colloidal gold; Combinatorial chemistry; Methacrylate; Methacrylic acid; Conjugated system; Chemistry; Protease; Materials science; Nanotechnology; Copolymer; Enzyme; Biochemistry; Polymer; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002833199,0.0004622159,0.000317652,0.0002098561,0.0001297068,0.0004334693,0.000218643,0.0005302386,0.0006247548],"category_scores_gemma":[0.0002714847,0.0003140781,0.0002674298,0.0002213005,0.0002526177,0.0004099983,0.0002387276,0.0003879934,0.0003831917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003814099,"about_ca_system_score_gemma":0.0001476928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001113316,"about_ca_topic_score_gemma":0.0002333921,"domain_scores_codex":[0.9997941,0.00004257216,0.00002153318,0.00006004277,0.00005093966,0.00003084442],"domain_scores_gemma":[0.9998579,0.00003204484,0.00004643455,0.00001694477,0.00002377991,0.00002274787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002481559,0.00001025017,0.00003148646,0.00001916311,0.000003689665,0.00001745577,0.000006588557,0.00009596983,0.9986959,0.00009185047,0.00001583209,0.0009870798],"study_design_scores_gemma":[0.000006460374,0.00007530161,0.000249095,0.000001106418,0.000007886812,0.0000645657,0.00000183498,0.0004299105,0.9980755,0.00002321047,0.001061969,0.000003183456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738236,0.002942597,0.01977094,0.0001572036,0.00005314568,0.00006719923,0.0001443738,0.0002261643,0.002814755],"genre_scores_gemma":[0.9817324,0.001013872,0.01382754,0.0001126222,0.00002452765,0.00007216617,0.0001705766,0.00003878561,0.003007332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006247548,"threshold_uncertainty_score":0.002767324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0130591615572262,"score_gpt":0.2406523326705145,"score_spread":0.2275931711132883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}