{"id":"W2270593503","doi":"10.1186/s13058-016-0672-x","title":"Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers","year":2016,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal University Hospital; Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research; Saskatchewan Health Research Foundation; Saskatchewan Cancer Agency","keywords":"Breast cancer; DNA methylation; Cancer research; Methylation; Cancer; Epigenetics; Gene silencing; Biology; Gene expression; Medicine; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001701246,0.0001714945,0.0002823669,0.000517937,0.0001788587,0.0002173899,0.0001602361,0.0001524898,0.001609553],"category_scores_gemma":[0.0002837605,0.00007958356,0.0001837663,0.0004372293,0.0001995201,0.00009699417,0.0001814138,0.0002512318,0.000227692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002499936,"about_ca_system_score_gemma":0.000185693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001104924,"about_ca_topic_score_gemma":0.001737502,"domain_scores_codex":[0.9998934,0.000009801809,0.000006766658,0.0000334365,0.00003698977,0.00001954669],"domain_scores_gemma":[0.999604,0.00003706561,0.000242571,0.00001993876,0.00004123834,0.00005509981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0014479,0.00006820586,0.1884122,0.0002390982,0.0001599313,0.0006517084,0.0001430168,0.0002390791,0.7911454,0.0001476072,0.0006006898,0.01674517],"study_design_scores_gemma":[0.00001824919,0.0002170595,0.9327092,0.00001658935,0.0001279362,0.00238962,0.0001280407,0.0006662974,0.06161559,0.0001854807,0.001912864,0.00001305965],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963937,0.001589357,0.0006001284,0.00006956134,0.000006406625,0.00000881548,0.0007132516,0.00002961196,0.00058916],"genre_scores_gemma":[0.9986023,0.0003092149,0.0002344122,0.00002308974,0.000007159098,0.000008663838,0.0004653807,0.00000603815,0.0003436662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001609553,"threshold_uncertainty_score":0.005384505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02635609729915074,"score_gpt":0.3185379014528618,"score_spread":0.292181804153711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}