{"id":"W2270593503","doi":"10.1186/s13058-016-0672-x","title":"Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers","year":2016,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal University Hospital; Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research; Saskatchewan Health Research Foundation; Saskatchewan Cancer Agency","keywords":"Breast cancer; DNA methylation; Cancer research; Methylation; Cancer; Epigenetics; Gene silencing; Biology; Gene expression; Medicine; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008507118,0.0003071962,0.0004072627,0.0002290056,0.0001384833,0.00004361907,0.0002254693,0.0001479395,0.0001314849],"category_scores_gemma":[0.00006320076,0.0002156332,0.00005569811,0.0007203562,0.0004483261,0.00003138558,0.00009740816,0.0001925399,0.000001215208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000680729,"about_ca_system_score_gemma":0.001049066,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01903381,"about_ca_topic_score_gemma":0.008821506,"domain_scores_codex":[0.9968354,0.0004463778,0.0004193367,0.0007918513,0.0008228602,0.0006841762],"domain_scores_gemma":[0.9983348,0.0001380631,0.0002805513,0.0003084349,0.0007119713,0.0002262274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001837913,0.0002064683,0.07736002,0.000171606,0.0006998676,0.0000056288,0.0008608553,0.0003039795,0.8738423,0.0000103955,0.000584982,0.04411596],"study_design_scores_gemma":[0.004088983,0.0007909382,0.2139928,0.0006799141,0.0001130961,0.00002119405,0.0004054418,0.0001942648,0.7791164,0.0001130155,0.00007780013,0.0004061861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911548,0.003189696,0.0003052743,0.001760123,0.00003397377,0.000991542,0.002511295,0.000009623079,0.00004368822],"genre_scores_gemma":[0.9957587,0.003035379,0.0002272245,0.00005174391,0.00006246655,0.0004161785,0.00006236806,0.00006162114,0.0003243363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1366328,"threshold_uncertainty_score":0.9874985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02635609729915074,"score_gpt":0.3185379014528618,"score_spread":0.292181804153711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}