{"id":"W2270731020","doi":"10.1007/s00439-015-1616-8","title":"Genetic variation in the immunosuppression pathway genes and breast cancer susceptibility: a pooled analysis of 42,510 cases and 40,577 controls from the Breast Cancer Association Consortium","year":2015,"lang":"en","type":"article","venue":"Human Genetics","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; McGill University; University of Toronto; Royal Victoria Hospital; Université Laval; Centre hospitalier universitaire de Québec","funders":"National Cancer Institute; Universitätsklinikum Hamburg-Eppendorf; Instituto de Salud Carlos III; Cancer Council South Australia; Medical Research Council; National Institutes of Health; Akershus Universitetssykehus; Guy's and St Thomas' NHS Foundation Trust; Deutschen Konsortium für Translationale Krebsforschung; Gesellschaft der Freunde der Medizinischen Hochschule Hannover; Rheinische Friedrich-Wilhelms-Universität Bonn; Ministero dello Sviluppo Economico; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Institut National Du Cancer; National Health and Medical Research Council; Oulun Yliopisto; Deutsche Krebshilfe; Medizinischen Hochschule Hannover; Norges Forskningsråd; Universitetet i Bergen; Kuopion Yliopistollinen Sairaala; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Stichting Tegen Kanker; Deutsche Gesetzliche Unfallversicherung; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; King's College London; Academy of Finland; Cancer Australia; Agence Nationale de la Recherche; Robert Bosch Stiftung; Yorkshire Cancer Research; VicHealth; National Breast Cancer Foundation; Cancer Council Western Australia; European Commission; Fondation du cancer du sein du Québec; Breakthrough Breast Cancer; National Institute for Health and Care Research; Susan G. Komen; McGill University Health Centre; University of California, Irvine; Kreftforeningen; David F. and Margaret T. Grohne Family Foundation; Cancer Research UK; Hamburger Krebsgesellschaft; Itä-Suomen Yliopisto; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Lon V. Smith Foundation; European Social Fund; Agency for Science, Technology and Research; Cancer Council Tasmania; Francis Crick Institute; Canadian Institutes of Health Research; Sigrid Juséliuksen Säätiö; General Secretariat for Research and Technology; Medisinske fakultet, Universitetet i Oslo; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Breast Cancer Research Foundation; McGill University; Helsingin ja Uudenmaan Sairaanhoitopiiri; Cancer Council NSW; Susan G. Komen for the Cure; KWF Kankerbestrijding; Nordic Cancer Union; Herlev Hospital; University of Southern California; Associazione Italiana per la Ricerca sul Cancro; Beckman Research Institute, City of Hope; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Fondation de France; Universitetet i Oslo; Sundhed og Sygdom, Det Frie Forskningsråd; Cancer Council Victoria; California Department of Public Health; Haukeland Universitetssjukehus; U.S. Department of Health and Human Services; University of Cambridge","keywords":"Biology; Breast cancer; Human genetics; Genetic variation; Gene; Immunosuppression; Cancer; Genetics; Genetic association; Oncology; Bioinformatics; Genotype; Single-nucleotide polymorphism; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005735895,0.0001705294,0.0003993838,0.00009842857,0.0001140158,0.00005582213,0.0001136301,0.0001261325,0.0001346507],"category_scores_gemma":[0.00004500351,0.0001054439,0.00009225171,0.0003421745,0.0001442697,0.00004038565,0.00004190996,0.0001252546,2.740172e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001961602,"about_ca_system_score_gemma":0.0001787918,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01673908,"about_ca_topic_score_gemma":0.01791739,"domain_scores_codex":[0.9983926,0.0003114744,0.0004434125,0.0002822969,0.0003755382,0.0001946661],"domain_scores_gemma":[0.99867,0.000327804,0.0003330716,0.0003628272,0.0002483043,0.00005792837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007967176,0.00009730062,0.8793135,0.00001888423,0.001207426,0.000004241674,0.003102669,0.00009070673,0.1059658,0.000004392234,0.0001540943,0.009244182],"study_design_scores_gemma":[0.002763957,0.0001036222,0.9918143,0.00007544539,0.002366014,0.00001689575,0.0009388145,0.0009480604,0.0006414566,0.00004184455,0.0001680113,0.0001215444],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769024,0.02028749,0.00001304073,0.001345402,0.00009335973,0.0004984071,0.0008384923,0.000009585321,0.0000118227],"genre_scores_gemma":[0.9961636,0.002950744,0.00003488182,0.0005152503,0.0001719999,0.00006412963,0.00004777788,0.00001426259,0.00003735976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1125008,"threshold_uncertainty_score":0.9998322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02388312822884823,"score_gpt":0.288781999868222,"score_spread":0.2648988716393737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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