{"id":"W2270731020","doi":"10.1007/s00439-015-1616-8","title":"Genetic variation in the immunosuppression pathway genes and breast cancer susceptibility: a pooled analysis of 42,510 cases and 40,577 controls from the Breast Cancer Association Consortium","year":2015,"lang":"en","type":"article","venue":"Human Genetics","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; McGill University; University of Toronto; Royal Victoria Hospital; Université Laval; Centre hospitalier universitaire de Québec","funders":"National Cancer Institute; Universitätsklinikum Hamburg-Eppendorf; Instituto de Salud Carlos III; Cancer Council South Australia; Medical Research Council; National Institutes of Health; Akershus Universitetssykehus; Guy's and St Thomas' NHS Foundation Trust; Deutschen Konsortium für Translationale Krebsforschung; Gesellschaft der Freunde der Medizinischen Hochschule Hannover; Rheinische Friedrich-Wilhelms-Universität Bonn; Ministero dello Sviluppo Economico; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Institut National Du Cancer; National Health and Medical Research Council; Oulun Yliopisto; Deutsche Krebshilfe; Medizinischen Hochschule Hannover; Norges Forskningsråd; Universitetet i Bergen; Kuopion Yliopistollinen Sairaala; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Stichting Tegen Kanker; Deutsche Gesetzliche Unfallversicherung; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; King's College London; Academy of Finland; Cancer Australia; Agence Nationale de la Recherche; Robert Bosch Stiftung; Yorkshire Cancer Research; VicHealth; National Breast Cancer Foundation; Cancer Council Western Australia; European Commission; Fondation du cancer du sein du Québec; Breakthrough Breast Cancer; National Institute for Health and Care Research; Susan G. Komen; McGill University Health Centre; University of California, Irvine; Kreftforeningen; David F. and Margaret T. Grohne Family Foundation; Cancer Research UK; Hamburger Krebsgesellschaft; Itä-Suomen Yliopisto; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Lon V. Smith Foundation; European Social Fund; Agency for Science, Technology and Research; Cancer Council Tasmania; Francis Crick Institute; Canadian Institutes of Health Research; Sigrid Juséliuksen Säätiö; General Secretariat for Research and Technology; Medisinske fakultet, Universitetet i Oslo; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Breast Cancer Research Foundation; McGill University; Helsingin ja Uudenmaan Sairaanhoitopiiri; Cancer Council NSW; Susan G. Komen for the Cure; KWF Kankerbestrijding; Nordic Cancer Union; Herlev Hospital; University of Southern California; Associazione Italiana per la Ricerca sul Cancro; Beckman Research Institute, City of Hope; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Fondation de France; Universitetet i Oslo; Sundhed og Sygdom, Det Frie Forskningsråd; Cancer Council Victoria; California Department of Public Health; Haukeland Universitetssjukehus; U.S. Department of Health and Human Services; University of Cambridge","keywords":"Biology; Breast cancer; Human genetics; Genetic variation; Gene; Immunosuppression; Cancer; Genetics; Genetic association; Oncology; Bioinformatics; Genotype; Single-nucleotide polymorphism; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002415712,0.0005827292,0.00144918,0.001094493,0.0006329559,0.0007177524,0.0005329232,0.0006478312,0.001696127],"category_scores_gemma":[0.002657884,0.0006393761,0.001353272,0.002235137,0.0003355874,0.0002290627,0.0005937328,0.0003648512,0.000230136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002859015,"about_ca_system_score_gemma":0.0002761289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006347217,"about_ca_topic_score_gemma":0.005839429,"domain_scores_codex":[0.9976881,0.0006013971,0.0002513325,0.001013827,0.0002988026,0.0001466161],"domain_scores_gemma":[0.9985331,0.0004329546,0.000351774,0.0003965013,0.0001761785,0.0001094457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001846699,0.0000491892,0.9825075,0.0001384782,0.006058201,0.0003448754,0.0001682023,0.0001901295,0.004086479,0.00007014963,0.0006202949,0.003919817],"study_design_scores_gemma":[0.0001016658,0.0001595379,0.9947155,0.00001818917,0.002865626,0.0005806444,0.00008513933,0.0003120317,0.0003339369,0.00006641106,0.000751252,0.00001010568],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941676,0.002580718,0.001145608,0.00003126288,0.00001578262,0.00003140227,0.001623198,0.0000209689,0.0003834619],"genre_scores_gemma":[0.9967679,0.0004476751,0.0004676318,0.0000329595,0.0000235094,0.00005116115,0.001945896,0.00001453474,0.0002486425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006347217,"threshold_uncertainty_score":0.01277566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02388312822884823,"score_gpt":0.288781999868222,"score_spread":0.2648988716393737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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