{"id":"W2270756322","doi":"10.1038/nchembio.2007","title":"A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1","year":2016,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":229,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Cancer Institute; Argonne National Laboratory; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Chromatin; BMI1; Histone; Biology; Histone H3; Epigenetics; Cell biology; Biochemistry; Cell growth; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002198833,0.0001727569,0.0002183965,0.00002157683,0.00004219752,0.000004932133,0.0003741202,0.0007413442,0.00004520801],"category_scores_gemma":[0.000759401,0.00009440735,0.000142129,0.000084664,0.000390262,0.000002011174,0.0002421416,0.0002407705,0.000004645143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001790859,"about_ca_system_score_gemma":0.00004271836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004212007,"about_ca_topic_score_gemma":6.25537e-7,"domain_scores_codex":[0.9987782,0.00009516197,0.0003019423,0.0004352853,0.0001010167,0.0002884519],"domain_scores_gemma":[0.9990563,0.0001109229,0.0001815694,0.0004286213,0.0001530939,0.00006948313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007309009,0.00004306467,0.001206887,0.000009479146,0.00004097424,7.539653e-7,0.00001530766,2.419627e-7,0.9952465,0.0008755666,0.0006449913,0.001843143],"study_design_scores_gemma":[0.0004570725,0.00008114607,0.0001678892,0.00001132881,0.00001478621,0.000002788016,0.000007113842,0.000006527456,0.9740993,0.002361556,0.02264635,0.0001441692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907765,0.003841014,0.00297758,0.001275526,0.0001288098,0.0002058897,0.00006631071,0.0000137907,0.0007145486],"genre_scores_gemma":[0.997178,0.0001296862,0.001689641,0.0002015227,0.0004833584,0.00001813491,0.0002278579,0.00001875979,0.0000530544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02200136,"threshold_uncertainty_score":0.5717925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009219692325741269,"score_gpt":0.2642607284701537,"score_spread":0.2550410361444124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}