{"id":"W2270849998","doi":"10.15252/embj.201591293","title":"BRPF3‐HBO1 regulates replication origin activation and histone H3K14 acetylation","year":2015,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":145,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; McGill University Health Centre; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Université Laval","funders":"Canadian Institutes of Health Research; Kræftens Bekæmpelse; Novo Nordisk Fonden; Lundbeckfonden; Danmarks Grundforskningsfond; Gentofte Hospital","keywords":"Biology; Acetylation; Histone; Cell biology; Replication (statistics); Biochemistry; DNA; Gene; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007569232,0.00007636534,0.00006373885,0.000025737,0.0001159122,0.00003951891,0.0001099768,0.00006133657,0.000009083523],"category_scores_gemma":[0.0001828206,0.00005578417,0.00002900817,0.00005090064,0.00003730517,0.00001190285,0.00004309598,0.00009997573,0.00000630219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004298924,"about_ca_system_score_gemma":0.00005801231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007325424,"about_ca_topic_score_gemma":0.00000264719,"domain_scores_codex":[0.9993674,0.00008584724,0.0001443194,0.0001578078,0.0001380748,0.000106568],"domain_scores_gemma":[0.999326,0.000008923653,0.0001446734,0.0003151632,0.0001298459,0.00007539629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008918468,0.00001626645,0.0002322526,0.000002394211,0.00002227782,5.675096e-7,0.0002057012,0.00008667909,0.9846569,0.0004788243,0.005259529,0.008949473],"study_design_scores_gemma":[0.0005798187,0.0001850142,0.002237141,0.00001400312,0.00002253262,0.000372998,0.000161835,0.0006592427,0.9551311,0.007297475,0.03321385,0.0001250086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903014,0.0003303742,0.006989648,0.001461861,0.0001422655,0.00009758234,7.617068e-7,0.00001255569,0.000663542],"genre_scores_gemma":[0.9964004,0.00007751823,0.001320378,0.0001606553,0.000431878,0.000005041828,0.00001959529,0.00001310405,0.001571438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02952576,"threshold_uncertainty_score":0.2274812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0256434573528922,"score_gpt":0.294458628941911,"score_spread":0.2688151715890189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}