{"id":"W2270967011","doi":"10.1080/2162402x.2015.1090077","title":"Pharmacological DNA demethylation: Implications for cancer immunotherapy","year":2015,"lang":"en","type":"article","venue":"OncoImmunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"DNA demethylation; Stimulator of interferon genes; IRF7; Interferon; MDA5; Viral infection; TLR7; Demethylation; Downregulation and upregulation; Cancer immunotherapy; Cancer research; Biology; DNA; Immunotherapy; Cancer; Interferon regulatory factors; DNA methylation; Virology; Innate immune system; Gene; Immunology; RNA; Immune system; Virus; Genetics; Gene expression; Toll-like receptor; RNA interference","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003670779,0.0002195601,0.0003755068,0.0001350269,0.0001913728,0.00001606838,0.0004082251,0.0003935297,0.0007458481],"category_scores_gemma":[0.0001620181,0.0001892302,0.0001534747,0.0001568337,0.0003456706,0.0001046933,0.00008296192,0.0002728004,0.0003730595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001725531,"about_ca_system_score_gemma":0.0002950543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008140022,"about_ca_topic_score_gemma":0.0000178968,"domain_scores_codex":[0.9984471,0.0003114609,0.0003882951,0.0003334047,0.0000220249,0.0004977235],"domain_scores_gemma":[0.9988598,0.0003451051,0.0001544362,0.0003185734,0.0002928787,0.00002919097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001691277,0.0001969769,0.001018135,0.00000326619,0.0004997664,5.839238e-7,0.0003983808,0.00000612971,0.9130582,0.007721417,0.02324745,0.05215849],"study_design_scores_gemma":[0.003908545,0.0007933241,0.01358673,0.000007674825,0.00006286254,0.00007843195,0.0002411038,0.00000369501,0.1544737,0.001515147,0.8250824,0.0002463706],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8745219,0.08348273,0.007072771,0.01922306,0.006856848,0.001601113,0.000191563,0.0009316417,0.006118392],"genre_scores_gemma":[0.9875291,0.0008901242,0.0004491415,0.001400385,0.0001035031,0.0009432216,0.0001462024,0.00005450428,0.008483842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8018349,"threshold_uncertainty_score":0.8166513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07756765969573012,"score_gpt":0.3729222530725165,"score_spread":0.2953545933767864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}