{"id":"W2270967011","doi":"10.1080/2162402x.2015.1090077","title":"Pharmacological DNA demethylation: Implications for cancer immunotherapy","year":2015,"lang":"en","type":"article","venue":"OncoImmunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"DNA demethylation; Stimulator of interferon genes; IRF7; Interferon; MDA5; Viral infection; TLR7; Demethylation; Downregulation and upregulation; Cancer immunotherapy; Cancer research; Biology; DNA; Immunotherapy; Cancer; Interferon regulatory factors; DNA methylation; Virology; Innate immune system; Gene; Immunology; RNA; Immune system; Virus; Genetics; Gene expression; Toll-like receptor; RNA interference","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005280912,0.0003425558,0.0003778693,0.0003677268,0.0002258634,0.0006112794,0.0004040861,0.0007119603,0.002856526],"category_scores_gemma":[0.0003125079,0.0001195263,0.0002699008,0.0002290199,0.0005131114,0.0006387329,0.0002752043,0.001404608,0.0004370696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004659051,"about_ca_system_score_gemma":0.0003492376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002332459,"about_ca_topic_score_gemma":0.0005587778,"domain_scores_codex":[0.999913,0.00002536009,0.000005516297,0.00001840975,0.00001686651,0.00002098435],"domain_scores_gemma":[0.9998784,0.00004935633,0.0000250028,0.00001250611,0.0000149568,0.00001981554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001122993,0.0008471618,0.001560393,0.00178987,0.00009566919,0.0004778453,0.0001554654,0.002417732,0.5656398,0.02398749,0.005783517,0.396122],"study_design_scores_gemma":[0.0006828051,0.008671233,0.008308161,0.0007027411,0.0002637577,0.004181614,0.0004887165,0.005586199,0.5839048,0.03870766,0.3484122,0.00009006674],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1562556,0.7552081,0.02970547,0.02366429,0.001529248,0.0003109968,0.0004627939,0.000361718,0.03250188],"genre_scores_gemma":[0.7034737,0.270192,0.01198155,0.003268649,0.001137347,0.0002716748,0.0003481938,0.00004030719,0.009286555],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002856526,"threshold_uncertainty_score":0.009555995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07756765969573012,"score_gpt":0.3729222530725165,"score_spread":0.2953545933767864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}