{"id":"W2271002166","doi":"10.1038/srep17311","title":"High Frequency of Imprinted Methylation Errors in Human Preimplantation Embryos","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Children’s Health Research Institute; Western University","funders":"Canadian Institutes of Health Research; Children's Health Research Institute","keywords":"Genomic imprinting; Blastocyst; Methylation; Andrology; Imprinting (psychology); Embryo; Biology; Infertility; DNA methylation; Reproductive technology; Embryo culture; Genetics; Pregnancy; Embryogenesis; Medicine; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001027438,0.00006993324,0.0001706301,0.0002254799,0.00003750781,0.00002040559,0.00004060838,0.00006000635,0.00002711177],"category_scores_gemma":[0.0007731487,0.00006168019,0.00003510971,0.0003865689,0.00008816995,0.000114168,0.0000268753,0.00008748139,0.000005895225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006032475,"about_ca_system_score_gemma":0.0001491965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001112979,"about_ca_topic_score_gemma":0.0001292359,"domain_scores_codex":[0.9986902,0.00003303893,0.0004563671,0.0002824704,0.0004016545,0.0001362235],"domain_scores_gemma":[0.999009,0.00002812977,0.0002459034,0.0003722222,0.0002261976,0.0001185838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005404385,0.0002584909,0.396815,0.00007957117,0.0000395479,0.001201938,0.001409941,0.0004273433,0.5943399,0.00094141,0.002314943,0.00211785],"study_design_scores_gemma":[0.001216848,0.0002226662,0.3421251,0.0002883002,0.0001166718,0.0005466313,0.0002740607,0.0003946767,0.6247354,0.02975461,0.0001337936,0.0001912086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952852,0.00004897981,0.0005843856,0.0000492928,0.001370173,0.0002471249,0.000002969876,0.00004095491,0.002370947],"genre_scores_gemma":[0.9967842,5.305105e-7,0.002396824,0.000007296248,0.00002580303,0.000008159245,0.0002843529,0.000006702798,0.0004861822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0546899,"threshold_uncertainty_score":0.2515245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03747680369081742,"score_gpt":0.3137251482343366,"score_spread":0.2762483445435192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}