{"id":"W2271002166","doi":"10.1038/srep17311","title":"High Frequency of Imprinted Methylation Errors in Human Preimplantation Embryos","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Children’s Health Research Institute; Western University","funders":"Canadian Institutes of Health Research; Children's Health Research Institute","keywords":"Genomic imprinting; Blastocyst; Methylation; Andrology; Imprinting (psychology); Embryo; Biology; Infertility; DNA methylation; Reproductive technology; Embryo culture; Genetics; Pregnancy; Embryogenesis; Medicine; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004188568,0.0001153466,0.0002060278,0.0007090633,0.0001854314,0.0002885264,0.0001877297,0.0002696542,0.001141442],"category_scores_gemma":[0.001333652,0.000118466,0.0001324927,0.0004143999,0.0002695999,0.0001351342,0.0002099405,0.0002293615,0.0002395646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001260949,"about_ca_system_score_gemma":0.0001170489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007986078,"about_ca_topic_score_gemma":0.0007711521,"domain_scores_codex":[0.999364,0.0001001701,0.00009199286,0.0001100368,0.0002723182,0.00006155157],"domain_scores_gemma":[0.9991092,0.0003678569,0.0002257696,0.0001353522,0.0001219708,0.00003979346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009054883,0.00004878949,0.5391315,0.0001812589,0.0001402784,0.003480963,0.0009971967,0.0004854987,0.4054047,0.0002324209,0.0002609152,0.04873102],"study_design_scores_gemma":[0.00000616607,0.000344172,0.8186112,0.00002470013,0.0001223819,0.01168814,0.0004361322,0.0004628601,0.1661885,0.0001710983,0.001930096,0.00001460481],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960728,0.001373932,0.001404257,0.00003436604,0.000008158596,0.0000124078,0.0001728052,0.00002194312,0.0008992092],"genre_scores_gemma":[0.9981598,0.0005979558,0.0006157297,0.00001754091,0.000006192512,0.00000667619,0.0001589119,0.000005683208,0.0004315087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001141442,"threshold_uncertainty_score":0.003818452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03747680369081742,"score_gpt":0.3137251482343366,"score_spread":0.2762483445435192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}