{"id":"W2271385869","doi":"10.4236/apd.2016.51001","title":"Inhibition of &amp;lt;i&amp;gt;foxo&amp;lt;/i&amp;gt; and &amp;lt;i&amp;gt;minibrain&amp;lt;/i&amp;gt; in Dopaminergic Neurons Can Model Aspects of Parkinson Disease in &amp;lt;i&amp;gt;Drosophila melanogaster&amp;lt;/i&amp;gt;","year":2016,"lang":"en","type":"article","venue":"Advances in Parkinson s Disease","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Natural Sciences and Engineering Research Council of Canada; Memorial University of Newfoundland","keywords":"Dopaminergic; Drosophila melanogaster; RNA interference; Tyrosine hydroxylase; Transcription factor; Biology; Cell biology; Dopamine; Genetics; Endocrinology; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008563599,0.0005083358,0.0002269585,0.0002793276,0.0001517911,0.0002516586,0.0003142501,0.0003601257,0.002261509],"category_scores_gemma":[0.00005548105,0.0001519792,0.0002935021,0.000138633,0.0003925247,0.0002122724,0.0001998408,0.0006476266,0.0005572857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004660375,"about_ca_system_score_gemma":0.0002352511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008304589,"about_ca_topic_score_gemma":0.002330986,"domain_scores_codex":[0.9998959,0.000009312452,0.00001237441,0.00003808235,0.00002707814,0.00001720986],"domain_scores_gemma":[0.9999427,0.000005573504,0.00002351475,0.000006357133,0.000004503482,0.00001735818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007910006,0.00002331258,0.00008577842,0.00004958322,0.000004661573,0.00002969572,0.000009498567,0.00007112562,0.9980105,0.0002952222,0.00008031238,0.001261286],"study_design_scores_gemma":[0.00002735811,0.0002763915,0.002276808,0.00001387719,0.00002209548,0.0001347995,0.00002090422,0.0006543157,0.9871637,0.00009263783,0.009310549,0.000006680963],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9710892,0.003195177,0.01203699,0.0004298598,0.0001577626,0.0001487003,0.003996371,0.000495133,0.008450666],"genre_scores_gemma":[0.9593228,0.002687649,0.01398532,0.0001951311,0.00002430359,0.0002628136,0.002778327,0.0001260058,0.02061765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002261509,"threshold_uncertainty_score":0.007565558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02976793750642957,"score_gpt":0.2742637267133921,"score_spread":0.2444957892069625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}