{"id":"W2271650132","doi":"10.1038/ncomms8415","title":"DJ-1 links muscle ROS production with metabolic reprogramming and systemic energy homeostasis in mice","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Waterloo; Toronto Rehabilitation Institute; University of Toronto; University Health Network","funders":"Banting and Best Diabetes Centre, University of Toronto; Eli Lilly Canada; Canadian Society of Endocrinology and Metabolism; Canadian Institutes of Health Research; Canadian Liver Foundation; University of Waterloo; Eli Lilly and Company","keywords":"Reactive oxygen species; Energy homeostasis; Cell biology; Mitochondrion; Mitochondrial ROS; Biology; Reprogramming; Skeletal muscle; Homeostasis; Glucose homeostasis; Insulin resistance; Endocrinology; Insulin; Biochemistry; Cell; Obesity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004815761,0.00079057,0.0004184226,0.001743189,0.0004833337,0.0007858707,0.0007590345,0.0009431887,0.00267675],"category_scores_gemma":[0.0003354013,0.0005625841,0.0005937752,0.0005083888,0.0007901152,0.0005474073,0.0006211992,0.001611356,0.0005367243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007291704,"about_ca_system_score_gemma":0.0004323252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007923704,"about_ca_topic_score_gemma":0.001237414,"domain_scores_codex":[0.9995734,0.00006579726,0.00006452935,0.0001265025,0.00008792344,0.00008181263],"domain_scores_gemma":[0.9993574,0.00006286484,0.0003215518,0.00004774453,0.0000284158,0.0001819448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006584861,0.0001771941,0.0004718693,0.00006749234,0.00002560098,0.0002345984,0.00004235244,0.0002274177,0.9954672,0.0006563804,0.0001578032,0.001813579],"study_design_scores_gemma":[0.000340338,0.001544943,0.01644693,0.00007555739,0.0001470032,0.002045633,0.0001455679,0.004039967,0.9674895,0.001214875,0.006467239,0.00004243801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853057,0.001996783,0.007709594,0.0007782609,0.0001274049,0.00008396293,0.001759564,0.0004056194,0.001833042],"genre_scores_gemma":[0.9815366,0.002604677,0.006394332,0.000364368,0.00006008962,0.0001553446,0.001559926,0.0002062702,0.007118419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00267675,"threshold_uncertainty_score":0.008954644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03010669992259112,"score_gpt":0.302382235082071,"score_spread":0.2722755351594799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}