{"id":"W2271650132","doi":"10.1038/ncomms8415","title":"DJ-1 links muscle ROS production with metabolic reprogramming and systemic energy homeostasis in mice","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Waterloo; Toronto Rehabilitation Institute; University of Toronto; University Health Network","funders":"Banting and Best Diabetes Centre, University of Toronto; Eli Lilly Canada; Canadian Society of Endocrinology and Metabolism; Canadian Institutes of Health Research; Canadian Liver Foundation; University of Waterloo; Eli Lilly and Company","keywords":"Reactive oxygen species; Energy homeostasis; Cell biology; Mitochondrion; Mitochondrial ROS; Biology; Reprogramming; Skeletal muscle; Homeostasis; Glucose homeostasis; Insulin resistance; Endocrinology; Insulin; Biochemistry; Cell; Obesity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003796707,0.0001256625,0.000283394,0.0001888485,0.00009607842,0.00002079121,0.0002171174,0.0003107798,0.000001124244],"category_scores_gemma":[0.0003072921,0.0001024119,0.00002690553,0.0005872906,0.00009498044,0.0001385099,0.0001182922,0.00094585,0.000004112932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004136844,"about_ca_system_score_gemma":0.0001228989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003246861,"about_ca_topic_score_gemma":0.001042985,"domain_scores_codex":[0.9990511,0.0001269848,0.0002199659,0.0002536126,0.0001769464,0.0001714072],"domain_scores_gemma":[0.9981349,0.0000443581,0.0001001689,0.001314307,0.0002652817,0.0001410098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004823174,0.001639882,0.05406136,0.0002761346,0.0005660811,0.00005694254,0.01837279,0.00004490422,0.02669214,0.06636457,0.006002227,0.8254406],"study_design_scores_gemma":[0.002387963,0.0001487531,0.06037419,0.0004437628,0.0006068738,0.0008188746,0.003574259,0.0001800957,0.003639961,0.0002504076,0.9272226,0.0003522729],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5699595,0.4162182,0.0001311825,0.01118804,0.0002188863,0.0006691415,0.000005382136,0.0001633567,0.001446314],"genre_scores_gemma":[0.9802051,0.005252699,0.01345802,0.0003100577,0.0001346951,0.0001045851,0.00007342667,0.0000250166,0.0004364088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9212204,"threshold_uncertainty_score":0.4176235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03010669992259112,"score_gpt":0.302382235082071,"score_spread":0.2722755351594799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}