{"id":"W2272246971","doi":"10.1038/nn.4228","title":"Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept","year":2016,"lang":"en","type":"review","venue":"Nature Neuroscience","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":234,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Scottish Mental Health Research Network; National Center for Research Resources; National Institute of Biomedical Imaging and Bioengineering; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Mental Health; Strategic Research Council; National Health and Medical Research Council; Knut och Alice Wallenbergs Stiftelse; European Commission; Canadian Institutes of Health Research; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital; Stanley Center for Psychiatric Research, Broad Institute; National Institutes of Health; Biogen; Højteknologifonden; Ramsay Health Care; H. Lundbeck A/S; Medical Research Council; Academy of Finland; Servier; Tartu Ülikool; Uppsala Universitet; University of New South Wales; Radboud Universitair Medisch Centrum; Universitair Medisch Centrum Groningen; Biomedical Research Council; Universitetet i Bergen; Karolinska Institutet; Lundbeckfonden; Accare; National Cancer Institute; European Regional Development Fund; Max-Planck-Gesellschaft; Bergens Forskningsstiftelse; Svenska Forskningsrådet Formas; Vrije Universiteit Amsterdam; Vetenskapsrådet; Universiteit Utrecht; Stockholms Läns Landsting; Norges Forskningsråd; National Medical Research Council; Universiteit Leiden; Australian Schizophrenia Research Bank; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Deutsche Forschungsgemeinschaft; Genentech; Bundesministerium für Bildung und Forschung; Medpace; Stanley Medical Research Institute; British Heart Foundation; Agency for Science, Technology and Research; Northern California Institute for Research and Education; Centre d'Imagerie BioMédicale; Eisai; Leids Universitair Medisch Centrum; Riksbankens Jubileumsfond; Foundation for the National Institutes of Health; National Alliance for Research on Schizophrenia and Depression; Hersenstichting; U.S. Department of Defense; Commonwealth Scientific and Industrial Research Organisation; National Institute for Health and Care Research; Pratt Foundation; NHS Blood and Transplant; Sylvia and Charles Viertel Charitable Foundation; Seventh Framework Programme; Novartis Pharmaceuticals Corporation; University of California, San Diego; Wellcome Trust; Johns Hopkins University; Pfizer; National Institute on Aging; Universität Greifswald; Australian Research Council; BioClinica; University of Melbourne; Science for Life Laboratory; Akademiska Sjukhuset; Harvard University; Broad Institute; Australian Government; F. Hoffmann-La Roche; Synarc; Max Planck Instituut voor Psycholinguïstiek; Eunice Kennedy Shriver National Institute of Child Health and Human Development; University of Southern California; Science Foundation Ireland; National Science Foundation; Scottish Funding Council; Massachusetts General Hospital; GlaxoSmithKline; Radboud Universiteit; Eli Lilly and Company; Alzheimer's Disease Neuroimaging Initiative; Max-Planck-Förderstiftung; Autism Speaks; Bristol-Myers Squibb; IXICO; Alfried Krupp von Bohlen und Halbach-Stiftung; Alzheimer's Association; National Institute of Neurological Disorders and Stroke; British Medical Association; U.S. Department of Veterans Affairs; Aarhus Universitet; Meso Scale Diagnostics; ZonMw; Strategiske Forskningsråd","keywords":"Schizophrenia (object-oriented programming); Genetic architecture; Heritability; Neuroscience; Imaging genetics; Genome-wide association study; Brain size; Neuroimaging; Genetic association; Genetic correlation; Endophenotype; Psychology; Phenotype; Genetic variation; Biology; Psychiatry; Genetics; Medicine; Cognition; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00152915,0.0008466903,0.00175566,0.001018042,0.0001702749,0.001069297,0.001013252,0.001119676,0.002412259],"category_scores_gemma":[0.002512192,0.0002369602,0.0008009998,0.001205339,0.0007269273,0.0007922174,0.0007479809,0.001400461,0.0005338421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006591163,"about_ca_system_score_gemma":0.001829951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0023838,"about_ca_topic_score_gemma":0.00402248,"domain_scores_codex":[0.9997296,0.000055698,0.00003751374,0.0000752913,0.00008020359,0.00002170216],"domain_scores_gemma":[0.998489,0.001057311,0.0001746045,0.00004201164,0.0001698249,0.00006712115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004231852,0.00005772104,0.004488575,0.0124629,0.001097477,0.0005403428,0.00006251737,0.0006838103,0.001681862,0.005506329,0.02003916,0.9529563],"study_design_scores_gemma":[0.0002171946,0.0003122149,0.03657392,0.01725549,0.004809727,0.005445605,0.0002734455,0.0004578934,0.001988273,0.0232348,0.9092752,0.0001563619],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003332203,0.9981627,0.0002406064,0.0006825438,0.0001242976,0.000002541344,0.00006819547,0.000006364351,0.0003795425],"genre_scores_gemma":[0.002420978,0.996458,0.0003125795,0.0003435284,0.0002249779,0.000004617409,0.00005767715,0.000002216043,0.0001753501],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002412259,"threshold_uncertainty_score":0.008087039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01385757268220297,"score_gpt":0.3159572239040588,"score_spread":0.3020996512218558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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