{"id":"W2272246971","doi":"10.1038/nn.4228","title":"Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept","year":2016,"lang":"en","type":"review","venue":"Nature Neuroscience","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":234,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Scottish Mental Health Research Network; National Center for Research Resources; National Institute of Biomedical Imaging and Bioengineering; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Mental Health; Strategic Research Council; National Health and Medical Research Council; Knut och Alice Wallenbergs Stiftelse; European Commission; Canadian Institutes of Health Research; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital; Stanley Center for Psychiatric Research, Broad Institute; National Institutes of Health; Biogen; Højteknologifonden; Ramsay Health Care; H. Lundbeck A/S; Medical Research Council; Academy of Finland; Servier; Tartu Ülikool; Uppsala Universitet; University of New South Wales; Radboud Universitair Medisch Centrum; Universitair Medisch Centrum Groningen; Biomedical Research Council; Universitetet i Bergen; Karolinska Institutet; Lundbeckfonden; Accare; National Cancer Institute; European Regional Development Fund; Max-Planck-Gesellschaft; Bergens Forskningsstiftelse; Svenska Forskningsrådet Formas; Vrije Universiteit Amsterdam; Vetenskapsrådet; Universiteit Utrecht; Stockholms Läns Landsting; Norges Forskningsråd; National Medical Research Council; Universiteit Leiden; Australian Schizophrenia Research Bank; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Deutsche Forschungsgemeinschaft; Genentech; Bundesministerium für Bildung und Forschung; Medpace; Stanley Medical Research Institute; British Heart Foundation; Agency for Science, Technology and Research; Northern California Institute for Research and Education; Centre d'Imagerie BioMédicale; Eisai; Leids Universitair Medisch Centrum; Riksbankens Jubileumsfond; Foundation for the National Institutes of Health; National Alliance for Research on Schizophrenia and Depression; Hersenstichting; U.S. Department of Defense; Commonwealth Scientific and Industrial Research Organisation; National Institute for Health and Care Research; Pratt Foundation; NHS Blood and Transplant; Sylvia and Charles Viertel Charitable Foundation; Seventh Framework Programme; Novartis Pharmaceuticals Corporation; University of California, San Diego; Wellcome Trust; Johns Hopkins University; Pfizer; National Institute on Aging; Universität Greifswald; Australian Research Council; BioClinica; University of Melbourne; Science for Life Laboratory; Akademiska Sjukhuset; Harvard University; Broad Institute; Australian Government; F. Hoffmann-La Roche; Synarc; Max Planck Instituut voor Psycholinguïstiek; Eunice Kennedy Shriver National Institute of Child Health and Human Development; University of Southern California; Science Foundation Ireland; National Science Foundation; Scottish Funding Council; Massachusetts General Hospital; GlaxoSmithKline; Radboud Universiteit; Eli Lilly and Company; Alzheimer's Disease Neuroimaging Initiative; Max-Planck-Förderstiftung; Autism Speaks; Bristol-Myers Squibb; IXICO; Alfried Krupp von Bohlen und Halbach-Stiftung; Alzheimer's Association; National Institute of Neurological Disorders and Stroke; British Medical Association; U.S. Department of Veterans Affairs; Aarhus Universitet; Meso Scale Diagnostics; ZonMw; Strategiske Forskningsråd","keywords":"Schizophrenia (object-oriented programming); Genetic architecture; Heritability; Neuroscience; Imaging genetics; Genome-wide association study; Brain size; Neuroimaging; Genetic association; Genetic correlation; Endophenotype; Psychology; Phenotype; Genetic variation; Biology; Psychiatry; Genetics; Medicine; Cognition; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002321667,0.0002641615,0.0006265351,0.00008132735,0.00007692742,0.00001397882,0.0003943816,0.0007407091,0.00001237317],"category_scores_gemma":[0.00145079,0.000178841,0.0001515871,0.000186894,0.0004267727,0.000002502993,0.0001813635,0.0003257683,0.00000411091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009206012,"about_ca_system_score_gemma":0.0001890941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001034515,"about_ca_topic_score_gemma":0.000006259842,"domain_scores_codex":[0.998133,0.0002310344,0.0003933745,0.0007210468,0.0001815516,0.0003399896],"domain_scores_gemma":[0.9989827,0.0001189647,0.0003310309,0.0004036903,0.00005329293,0.0001103449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003157104,0.0001778844,0.002748789,0.00104842,0.00004273652,0.000007445882,0.00002489463,0.00001245264,0.003305158,0.0003888764,0.01054043,0.9816713],"study_design_scores_gemma":[0.0002562047,0.0004905427,0.004807496,0.0006508094,0.00005348646,0.00003392558,0.0000032576,0.00002349857,0.0002477722,0.00005191216,0.9931058,0.0002753539],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006297142,0.9919725,0.0004928279,0.0001149086,0.0003223866,0.0003849014,0.0001164413,0.000009106156,0.0002897556],"genre_scores_gemma":[0.02103418,0.9759801,0.0006548018,0.0006290812,0.0002199547,0.00003806522,0.00001479067,0.00004368857,0.001385359],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9825653,"threshold_uncertainty_score":0.7292924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01385757268220297,"score_gpt":0.3159572239040588,"score_spread":0.3020996512218558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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