{"id":"W2272426771","doi":"10.1371/journal.pgen.1005827","title":"Staufen1 Regulates Multiple Alternative Splicing Events either Positively or Negatively in DM1 Indicating Its Role as a Disease Modifier","year":2016,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; University of Ottawa","funders":"University of Toronto; Canadian Institutes of Health Research; University of Ottawa; Muscular Dystrophy Association","keywords":"Biology; RNA splicing; Exon; Alternative splicing; Exon skipping; RNA-binding protein; Genetics; Untranslated region; Intron; Cell biology; Gene; Exonic splicing enhancer; Messenger RNA; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009997531,0.0004373342,0.000219263,0.0003632639,0.0002641958,0.0003279862,0.0001534905,0.000263211,0.001380464],"category_scores_gemma":[0.000114481,0.0001541898,0.0002377672,0.0002704603,0.0001782895,0.0001467034,0.0001867786,0.0003104666,0.0005806413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000348477,"about_ca_system_score_gemma":0.0001381106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006468866,"about_ca_topic_score_gemma":0.001262498,"domain_scores_codex":[0.9998549,0.00002022436,0.00000933258,0.00004449545,0.00004749982,0.00002343008],"domain_scores_gemma":[0.9999195,0.00001802131,0.0000310574,0.000005804276,0.000009068584,0.00001648152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008726591,0.00001127493,0.0006966555,0.00003549109,0.000006363596,0.00006132521,0.00000979045,0.00005431237,0.997579,0.00007604554,0.0000473078,0.001335096],"study_design_scores_gemma":[0.00001287841,0.0001366165,0.03926839,0.00001225185,0.00003353191,0.0005538568,0.00003628383,0.001241219,0.9529281,0.0001010314,0.005669106,0.000006787196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878715,0.007798342,0.00181146,0.0001397862,0.00003205314,0.00001332222,0.0008011636,0.0001212318,0.001411202],"genre_scores_gemma":[0.9892349,0.003315756,0.00152324,0.00008134561,0.00001238885,0.00002110936,0.001644643,0.00002301544,0.004143729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001380464,"threshold_uncertainty_score":0.004618168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05008809185240774,"score_gpt":0.2828195790357805,"score_spread":0.2327314871833727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}