{"id":"W2272568747","doi":"10.1093/annonc/mdv262.08","title":"LBA-08 Results of a phase 1b study of the selective BRAF V600 inhibitor encorafenib in combination with cetuximab alone or cetuximab + alpelisib for treatment of patients with advanced BRAF-mutant metastatic colorectal cancer","year":2015,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Cetuximab; Medicine; Oncology; Internal medicine; Colorectal cancer; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003167052,0.002241787,0.003090472,0.000556425,0.0006311273,0.001284497,0.001450534,0.002133022,0.005109694],"category_scores_gemma":[0.001861388,0.001094276,0.003228936,0.0004569242,0.001353543,0.001211943,0.0005004227,0.005921656,0.001847461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001670989,"about_ca_system_score_gemma":0.002612464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003046634,"about_ca_topic_score_gemma":0.01091384,"domain_scores_codex":[0.9989585,0.0005734076,0.00005158794,0.0001302452,0.0001109151,0.0001754765],"domain_scores_gemma":[0.998626,0.0002681908,0.0002261915,0.0001044266,0.0001281473,0.0006471605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7267147,0.07721805,0.006635501,0.001278118,0.005428191,0.0003247004,0.000309736,0.004247265,0.04505192,0.0005446873,0.01891239,0.1133347],"study_design_scores_gemma":[0.6281528,0.3374312,0.01766632,0.00007408961,0.002208591,0.0003472817,0.00008833116,0.000988326,0.003760317,0.0002892943,0.008933011,0.00006050871],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.96806,0.007451786,0.0009184591,0.003741476,0.000720325,0.002929028,0.008414212,0.0003710804,0.007393584],"genre_scores_gemma":[0.9518176,0.005882815,0.004555606,0.004630896,0.0005356039,0.003218472,0.01933588,0.0002124743,0.009810657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005109694,"threshold_uncertainty_score":0.01709366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07104973586052514,"score_gpt":0.3944978731051367,"score_spread":0.3234481372446116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}