{"id":"W2272628097","doi":"10.1136/bmj.h5453","title":"Poor quality animal studies cause clinical trials to follow false leads","year":2015,"lang":"en","type":"letter","venue":"BMJ","topic":"Animal testing and alternatives","field":"Veterinary","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Quality (philosophy); Clinical trial; Intensive care medicine; Medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.01799827,0.0005919859,0.002563113,0.0001415378,0.0001211987,0.0000988499,0.0006110005,0.0007322395,0.0001061128],"category_scores_gemma":[0.04996603,0.0004621766,0.0007444696,0.0001485434,0.0002029435,0.0001007622,0.0005276428,0.00173305,0.001791336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001341177,"about_ca_system_score_gemma":0.0002223036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001699571,"about_ca_topic_score_gemma":0.00001979873,"domain_scores_codex":[0.9891253,0.00579477,0.002617047,0.001022433,0.0008335715,0.0006068694],"domain_scores_gemma":[0.9901704,0.007050955,0.001272656,0.0008010516,0.0004870759,0.0002178762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001470345,0.00007272937,0.002196067,0.0001543166,0.0008302213,0.002849441,0.0003300175,2.459071e-7,0.0001536125,0.0000254046,0.9903727,0.00154489],"study_design_scores_gemma":[0.001342899,0.004651222,0.003707736,0.0004370589,0.0003394492,0.0001080044,0.0003583187,0.000006286217,0.00001367076,0.000437045,0.9877008,0.0008974767],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.3489163,0.001487697,0.00003226795,0.6391425,0.003414176,0.001622154,0.0005769848,0.0005121575,0.004295782],"genre_scores_gemma":[0.1104522,0.00009926683,0.004819101,0.7593406,0.07832636,0.0004374968,0.0001862418,0.0002775228,0.04606122],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2384641,"threshold_uncertainty_score":0.999783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.854320461833502,"score_gpt":0.6505099326271196,"score_spread":0.2038105292063823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}