{"id":"W2272650560","doi":"10.1073/pnas.1525098113","title":"CD8 <sup>+</sup> CD122 <sup>+</sup> CD49d <sup>low</sup> regulatory T cells maintain T-cell homeostasis by killing activated T cells via Fas/FasL-mediated cytotoxicity","year":2016,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Biology; Cytotoxic T cell; Fas ligand; CD8; Immune system; Population; Cell biology; Molecular biology; Immunology; In vitro; Apoptosis; Programmed cell death; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001674677,0.0005186116,0.0002965228,0.0002672534,0.0001447006,0.0005242862,0.000205565,0.000316278,0.004572395],"category_scores_gemma":[0.0001684676,0.000135463,0.0001853222,0.0001456252,0.0002318889,0.0002718097,0.0001922336,0.001106221,0.00204765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001840367,"about_ca_system_score_gemma":0.0001069872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002055852,"about_ca_topic_score_gemma":0.0003517835,"domain_scores_codex":[0.9996886,0.00005287719,0.00004269085,0.00005437856,0.00008421986,0.00007724654],"domain_scores_gemma":[0.9997987,0.00002913822,0.00005078991,0.00004394738,0.00002769676,0.0000497679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001513543,0.00002583092,0.0003383568,0.00002492614,0.000002730906,0.00007387154,0.000008141434,0.00004852766,0.9966827,0.0001010565,0.0001411829,0.002401242],"study_design_scores_gemma":[0.00004704852,0.0004441925,0.005086482,0.000008359272,0.00002166746,0.0008166074,0.00003729184,0.001259093,0.9854636,0.0001227941,0.006685627,0.000007285471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801239,0.002166014,0.00940568,0.0003575557,0.0001411921,0.00008099794,0.001594201,0.0004676002,0.005662884],"genre_scores_gemma":[0.9840273,0.0005311677,0.005218753,0.0001688731,0.0000916838,0.0001088506,0.001736181,0.00009366256,0.008023563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004572395,"threshold_uncertainty_score":0.01529616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01356580549739549,"score_gpt":0.2294251884402937,"score_spread":0.2158593829428982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}