{"id":"W2272774995","doi":"10.1101/gad.261115.115","title":"Structure–function studies of histone H3/H4 tetramer maintenance during transcription by chaperone Spt2","year":2015,"lang":"en","type":"article","venue":"Genes & Development","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"Argonne National Laboratory; National Center for Research Resources; National Institute of General Medical Sciences; Office of Science; National Cancer Institute; National Institutes of Health; Office of Research Infrastructure Programs, National Institutes of Health; Canadian Institutes of Health Research; Leukemia and Lymphoma Society; National Institute for Health and Care Research; Starr Foundation","keywords":"Biology; Tetramer; Histone H3; Nucleosome; Chaperone (clinical); Cell biology; Histone octamer; Histone; Transcription (linguistics); RNA polymerase II; Histone code; Biochemistry; DNA; Promoter; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001525023,0.0002793222,0.0001770785,0.00009556216,0.000210572,0.0001787257,0.0003142767,0.0001927381,0.0008000698],"category_scores_gemma":[0.0001299459,0.000111393,0.0002329545,0.0002037811,0.0002052584,0.0001885237,0.0001364074,0.0005108967,0.0002194065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000458715,"about_ca_system_score_gemma":0.0001964428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001525528,"about_ca_topic_score_gemma":0.001572764,"domain_scores_codex":[0.9999526,0.000007619707,0.000002663045,0.00001227982,0.00001680383,0.000008169258],"domain_scores_gemma":[0.9999439,0.000009681157,0.00001350518,0.000004376372,0.00001171264,0.0000169902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000195056,0.00003402679,0.001291792,0.000057478,0.0000127033,0.0001287502,0.00003242796,0.001361922,0.99473,0.0002357735,0.0001136162,0.001806455],"study_design_scores_gemma":[0.00005169764,0.0002142738,0.009592437,0.000005563875,0.00002402378,0.0003891946,0.00005859759,0.02037498,0.9667563,0.0001312702,0.002391386,0.00001029251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996905,0.0004909755,0.002021418,0.00006863994,0.000009943084,0.000004853115,0.0001068216,0.00003526535,0.000357046],"genre_scores_gemma":[0.9968084,0.0004366279,0.001581628,0.00001543271,0.00000468616,0.000006532961,0.0004292543,0.00001474386,0.0007026975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001525528,"threshold_uncertainty_score":0.003328264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01368393751122427,"score_gpt":0.2502645832304845,"score_spread":0.2365806457192602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}