{"id":"W2272774995","doi":"10.1101/gad.261115.115","title":"Structure–function studies of histone H3/H4 tetramer maintenance during transcription by chaperone Spt2","year":2015,"lang":"en","type":"article","venue":"Genes & Development","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"Argonne National Laboratory; National Center for Research Resources; National Institute of General Medical Sciences; Office of Science; National Cancer Institute; National Institutes of Health; Office of Research Infrastructure Programs, National Institutes of Health; Canadian Institutes of Health Research; Leukemia and Lymphoma Society; National Institute for Health and Care Research; Starr Foundation","keywords":"Biology; Tetramer; Histone H3; Nucleosome; Chaperone (clinical); Cell biology; Histone octamer; Histone; Transcription (linguistics); RNA polymerase II; Histone code; Biochemistry; DNA; Promoter; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001051821,0.000156027,0.000168339,0.00003159736,0.00006524827,0.000007131104,0.0001051764,0.00008472145,0.000007383846],"category_scores_gemma":[0.00001369346,0.0001452002,0.00003697037,0.00005246036,0.00006167559,0.000003836597,0.00005734789,0.00004295108,0.000003386109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009389857,"about_ca_system_score_gemma":0.00009245623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006650923,"about_ca_topic_score_gemma":0.00004618601,"domain_scores_codex":[0.999094,0.00001763275,0.0002815651,0.0002610135,0.0001463836,0.000199385],"domain_scores_gemma":[0.9995121,0.000001793222,0.0001079284,0.0001706218,0.0001435503,0.00006395996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007218448,0.0000324985,0.0005894621,0.00005033119,0.0001177722,6.528107e-7,0.0005412649,0.0001851684,0.9916826,0.00001832882,0.0008879212,0.005821764],"study_design_scores_gemma":[0.0008690612,0.0001553265,0.008651784,0.0000242631,0.00002765801,0.00001385805,0.0008353743,0.00003895697,0.9508637,0.000122875,0.03811885,0.0002782819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901779,0.006940969,0.002216727,0.00005325238,0.0003829756,0.0001247481,0.00001777169,0.000009337416,0.00007634961],"genre_scores_gemma":[0.9924484,0.0007868268,0.005481572,0.0000588342,0.00005984254,0.00001587523,0.0001656492,0.00001959846,0.0009633946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04081894,"threshold_uncertainty_score":0.5921091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01368393751122427,"score_gpt":0.2502645832304845,"score_spread":0.2365806457192602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}