{"id":"W2273105472","doi":"10.1096/fasebj.22.1_supplement.812.3","title":"Transmembrane domain 1 of human dopamine D1 and D5 receptors is a crucial structural determinant for ligand affinity and selectivity","year":2008,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Receptor; Dopamine receptor; Transmembrane domain; Ligand (biochemistry); Chemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001562009,0.0001654914,0.0002095793,0.0001022529,0.0001476666,0.0003461742,0.0001428817,0.0002974986,0.001350973],"category_scores_gemma":[0.0002000907,0.00008504193,0.0002654327,0.0001111937,0.0001294027,0.000154546,0.0001513347,0.0002240093,0.0005809317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003004215,"about_ca_system_score_gemma":0.0001477894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006714765,"about_ca_topic_score_gemma":0.0005834225,"domain_scores_codex":[0.9998577,0.00003483858,0.00001238444,0.00002820889,0.00003456299,0.0000323279],"domain_scores_gemma":[0.9999104,0.00002092203,0.00002910773,0.00000665644,0.00001107305,0.00002190016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001750153,0.000007685825,0.0009684453,0.00004845658,0.000006537884,0.0001205596,0.00002776772,0.00009488643,0.9952543,0.0002593507,0.00006574533,0.002971278],"study_design_scores_gemma":[0.00005613151,0.0006171998,0.05668474,0.00004504087,0.00007249162,0.00368755,0.0002064056,0.003640119,0.918692,0.0003260766,0.01594887,0.00002323446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991831,0.002544101,0.003819131,0.0001389134,0.00001933863,0.00001916542,0.0003214592,0.00003367494,0.001273209],"genre_scores_gemma":[0.9960545,0.0006888274,0.001895304,0.00007404504,0.000006810795,0.000008645683,0.0004513061,0.000006754321,0.0008137835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001350973,"threshold_uncertainty_score":0.004519463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01525854175124874,"score_gpt":0.2499855494710649,"score_spread":0.2347270077198162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}