{"id":"W2273212585","doi":"10.2337/db15-0516","title":"Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes","year":2015,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juvenile Diabetes Research Foundation","funders":"Cambridge Institute for Medical Research, University of Cambridge; National Institute for Health and Care Research; NIHR Cambridge Biomedical Research Centre; Wellcome Trust; Wellcome; Juvenile Diabetes Research Foundation International","keywords":"FOXP3; Immunology; Biology; Regulatory T cell; Pathogenesis; Immune tolerance; Signal transduction; Immune system; T cell; Peripheral tolerance; Endocrinology; IL-2 receptor; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003028359,0.000256487,0.000256388,0.0006372259,0.0002910438,0.0003789168,0.0001337257,0.0003183438,0.0007233274],"category_scores_gemma":[0.0007364218,0.0001758502,0.0001802635,0.0003630629,0.0002617922,0.0001786622,0.0002097237,0.0003285141,0.0001282911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001453205,"about_ca_system_score_gemma":0.00006891228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009941534,"about_ca_topic_score_gemma":0.001235012,"domain_scores_codex":[0.9997316,0.00008571347,0.00002512398,0.00007781544,0.00003834919,0.00004131947],"domain_scores_gemma":[0.9995383,0.0001439914,0.0001310633,0.00004700162,0.00003347985,0.0001061621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001653952,0.0002351047,0.9284233,0.00001798358,0.0001351455,0.0005114262,0.0003266398,0.0001905782,0.06226408,0.00004672921,0.00007968154,0.00611547],"study_design_scores_gemma":[0.000006628004,0.0002558515,0.9973465,0.000002041309,0.00003032963,0.0005857443,0.00007274022,0.000154628,0.001430037,0.00002674818,0.00008338252,0.000005275936],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997178,0.00007709042,0.00007087579,0.000004168331,0.00000159769,0.000001359214,0.00002699529,0.000002006442,0.00009820142],"genre_scores_gemma":[0.9997234,0.00002968143,0.00008368285,0.000009708532,0.000002561134,0.000002128153,0.00005249594,0.000002412477,0.00009390088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009941534,"threshold_uncertainty_score":0.00241977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006104019364503543,"score_gpt":0.2054521776194697,"score_spread":0.1993481582549661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}