{"id":"W2273212585","doi":"10.2337/db15-0516","title":"Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes","year":2015,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juvenile Diabetes Research Foundation","funders":"Cambridge Institute for Medical Research, University of Cambridge; National Institute for Health and Care Research; NIHR Cambridge Biomedical Research Centre; Wellcome Trust; Wellcome; Juvenile Diabetes Research Foundation International","keywords":"FOXP3; Immunology; Biology; Regulatory T cell; Pathogenesis; Immune tolerance; Signal transduction; Immune system; T cell; Peripheral tolerance; Endocrinology; IL-2 receptor; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000540566,0.0001561054,0.0001771389,0.0001187937,0.00003090054,0.00005096728,0.00005744614,0.0001348291,0.00000211965],"category_scores_gemma":[0.0001494288,0.0001411366,0.00002097756,0.0002395399,0.00006763677,0.0000329882,0.00005194903,0.0001260256,0.000002114489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004267822,"about_ca_system_score_gemma":0.00006518813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004163675,"about_ca_topic_score_gemma":0.0002219514,"domain_scores_codex":[0.9989495,0.000125837,0.0001753002,0.0003101945,0.0001378102,0.000301378],"domain_scores_gemma":[0.9995969,0.000036497,0.00009923295,0.0001307869,0.00007540101,0.00006115869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0000111848,0.00004490156,0.851184,0.000017626,0.00002804915,9.078395e-7,0.00014054,0.00009835629,0.1478688,0.00001828023,0.00004694021,0.0005403912],"study_design_scores_gemma":[0.001167067,0.000371189,0.9611878,0.00008258935,0.00002247987,2.054245e-7,0.0002473238,0.000258195,0.03579175,0.0005210366,0.00008427122,0.0002660582],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969903,0.002411384,0.000005640236,0.00004704055,0.0001366537,0.0001383171,0.000008318239,0.00001324104,0.0002491323],"genre_scores_gemma":[0.9995112,0.00002947385,0.0001017784,0.0001622733,0.00004053605,0.00001225822,0.00009555757,0.0000157788,0.00003113836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1120771,"threshold_uncertainty_score":0.5755383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006104019364503543,"score_gpt":0.2054521776194697,"score_spread":0.1993481582549661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}