{"id":"W2273214088","doi":"10.1007/s11745-015-4110-0","title":"Reduced Mitochondrial Function in Human Huntington Disease Lymphoblasts is Not Due to Alterations in Cardiolipin Metabolism or Mitochondrial Supercomplex Assembly","year":2016,"lang":"en","type":"article","venue":"Lipids","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Cardiolipin; Biology; Mitochondrion; Lymphoblast; Mitochondrial disease; Trinucleotide repeat expansion; Huntington's disease; Mitochondrial Encephalomyopathies; Mitochondrial myopathy; Internal medicine; Endocrinology; Biochemistry; Mitochondrial DNA; Genetics; Cell culture; Disease; Medicine; Gene; Phospholipid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001102135,0.0002048572,0.0001562452,0.0001572343,0.000113324,0.0002523719,0.00007942245,0.0001634887,0.000836068],"category_scores_gemma":[0.0001837616,0.0001046258,0.0001197012,0.0001228655,0.0001500409,0.0001427206,0.0001742929,0.0001580551,0.0003618094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001778029,"about_ca_system_score_gemma":0.00008192769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004474926,"about_ca_topic_score_gemma":0.0004076238,"domain_scores_codex":[0.9999154,0.00001759839,0.00001361741,0.00002706111,0.00001490097,0.00001145599],"domain_scores_gemma":[0.9999033,0.00002184934,0.0000247132,0.00002071963,0.00001228841,0.00001716326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003621892,0.00001006231,0.001927361,0.0000240009,0.000006319815,0.0001238794,0.00004133795,0.00002393194,0.9968982,0.00003209495,0.00001740549,0.000533284],"study_design_scores_gemma":[0.00008440582,0.001010675,0.113471,0.00001931106,0.00006905815,0.002504584,0.0002698911,0.00063821,0.8777487,0.0001544368,0.004017273,0.00001235618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976463,0.0008627849,0.0006245733,0.00002208418,0.000006995609,0.000008865275,0.0004136412,0.00002333097,0.0003913623],"genre_scores_gemma":[0.9979564,0.0002598841,0.0003287794,0.00001364843,0.000002568568,0.00001179188,0.0008540454,0.000007890099,0.0005648541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000836068,"threshold_uncertainty_score":0.002796948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03524005370243014,"score_gpt":0.2874326822370975,"score_spread":0.2521926285346673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}