{"id":"W2273214088","doi":"10.1007/s11745-015-4110-0","title":"Reduced Mitochondrial Function in Human Huntington Disease Lymphoblasts is Not Due to Alterations in Cardiolipin Metabolism or Mitochondrial Supercomplex Assembly","year":2016,"lang":"en","type":"article","venue":"Lipids","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Cardiolipin; Biology; Mitochondrion; Lymphoblast; Mitochondrial disease; Trinucleotide repeat expansion; Huntington's disease; Mitochondrial Encephalomyopathies; Mitochondrial myopathy; Internal medicine; Endocrinology; Biochemistry; Mitochondrial DNA; Genetics; Cell culture; Disease; Medicine; Gene; Phospholipid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001049054,0.00041917,0.0005109934,0.0005656873,0.0002356936,0.0001803786,0.0004659775,0.0001027855,0.0003095219],"category_scores_gemma":[0.001759042,0.000332292,0.0001970894,0.0008620992,0.0001048181,0.0004535866,0.0001988539,0.0001460064,0.0002093242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001603686,"about_ca_system_score_gemma":0.0002795003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001467544,"about_ca_topic_score_gemma":0.0003967413,"domain_scores_codex":[0.9958738,0.0007232255,0.0007054665,0.001346487,0.0006299792,0.0007210471],"domain_scores_gemma":[0.9982774,0.0002935061,0.0000980718,0.0007834157,0.00009183225,0.0004557816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001205277,0.0002209599,0.0005363334,0.00001245107,0.0000055342,0.00002108562,0.0003286056,0.0002214867,0.9933171,0.0005344021,0.002730672,0.0008660969],"study_design_scores_gemma":[0.00339648,0.0001686578,0.09317515,0.00009077232,0.00003954688,0.000003776862,0.0000274002,0.0001171917,0.8970535,0.0002055266,0.005238193,0.0004838443],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911364,0.000009058033,0.001052542,0.001713347,0.004425273,0.001120845,0.0002648715,0.0000997659,0.0001779169],"genre_scores_gemma":[0.9927002,0.000007170095,0.0003042221,0.002132368,0.003029268,0.000477522,0.00001363879,0.00006921809,0.001266347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09626363,"threshold_uncertainty_score":0.9999129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03524005370243014,"score_gpt":0.2874326822370975,"score_spread":0.2521926285346673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}