{"id":"W2273220476","doi":"10.1128/mbio.01516-15","title":"Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences","year":2016,"lang":"en","type":"article","venue":"mBio","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs; Ministry of Education, Culture, Sports, Science and Technology; University of Toronto; Michael Smith Health Research BC; University of Oxford; George Washington University","keywords":"Downregulation and upregulation; Biology; Human leukocyte antigen; Mutagenesis; clone (Java method); Effector; Virology; Mutant; Molecular biology; Cell biology; Genetics; Gene; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002236659,0.0001662942,0.0001778862,0.0001133768,0.0001105746,0.000239377,0.0001693097,0.0003008208,0.001851342],"category_scores_gemma":[0.0004857986,0.00005387096,0.0001083892,0.00007777885,0.0001497144,0.0001004522,0.0001259867,0.0002786562,0.0004075395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009924392,"about_ca_system_score_gemma":0.00005390786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001335412,"about_ca_topic_score_gemma":0.00007587249,"domain_scores_codex":[0.9998518,0.00004465647,0.00001780229,0.00003649596,0.00002058564,0.00002862132],"domain_scores_gemma":[0.9997271,0.0001077295,0.00004938342,0.00003341765,0.00004068093,0.00004178366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002386457,0.00003183227,0.004197767,0.0000306498,0.000009209862,0.00005846804,0.00002750907,0.00006021137,0.9924347,0.00003819351,0.00001698471,0.002855866],"study_design_scores_gemma":[0.00003671487,0.001563046,0.05781164,0.0000163427,0.00004674492,0.003897809,0.00009726224,0.0009219865,0.9326532,0.00007273976,0.002875723,0.000006811807],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983754,0.0006263834,0.0006176516,0.00001535295,0.000005394443,0.00000858338,0.00005167552,0.000008721309,0.0002909232],"genre_scores_gemma":[0.9986233,0.0001969436,0.000705288,0.00002254807,0.000006410498,0.00001367425,0.000176262,0.000005498428,0.0002501247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001851342,"threshold_uncertainty_score":0.006193399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009860170867656887,"score_gpt":0.254185086709965,"score_spread":0.2443249158423081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}