{"id":"W2273246571","doi":"10.1038/ncomms9554","title":"Systematic analysis of somatic mutations impacting gene expression in 12 tumour types","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia Hospital; University of British Columbia; University of Toronto; BC Cancer Agency","funders":"Canadian Cancer Society Research Institute; Genome British Columbia; Michael Smith Health Research BC; BC Cancer Foundation; Genome Canada","keywords":"Biology; Somatic cell; Genetics; Gene; Computational biology; Mutation; Gene expression; Germline mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002557659,0.00007085171,0.0001972789,0.0001629435,0.00004579611,0.00001359301,0.0003809582,0.0001293783,0.000002218377],"category_scores_gemma":[0.001003617,0.00006628641,0.00007891901,0.0003138635,0.00003579515,0.000003792907,0.0001743482,0.0001427002,0.000001894411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003383446,"about_ca_system_score_gemma":0.0001017295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004153905,"about_ca_topic_score_gemma":0.001424933,"domain_scores_codex":[0.9993372,0.0001037155,0.0002825538,0.0001042287,0.00008612312,0.00008619932],"domain_scores_gemma":[0.9985792,0.0001581996,0.0001716405,0.0009145327,0.0001251395,0.0000512742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003749542,0.0004755786,0.05911393,0.0005900203,0.001020839,0.000001615462,0.002107771,0.01711986,0.9169499,0.001211365,0.001271387,0.0001002076],"study_design_scores_gemma":[0.004230296,0.0005431353,0.1761659,0.003089757,0.00670734,0.00003836365,0.01021079,0.07363282,0.7189119,0.002093151,0.002644162,0.00173237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743378,0.02201305,0.001174516,0.000337725,0.000110718,0.0003731174,0.00009460122,0.00001114435,0.001547395],"genre_scores_gemma":[0.9923172,0.0003105481,0.006854387,0.00005357455,0.00001773486,0.00003547195,0.0003820994,0.000008506023,0.00002045102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.198038,"threshold_uncertainty_score":0.2703081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01997073186673607,"score_gpt":0.3127720577749151,"score_spread":0.292801325908179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}