{"id":"W2273365605","doi":"10.1371/journal.pone.0148097","title":"The GTPase ARF6 Controls ROS Production to Mediate Angiotensin II-Induced Vascular Smooth Muscle Cell Proliferation","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"NADPH oxidase; Angiotensin II; NOX1; Cell biology; Vascular smooth muscle; Small GTPase; RAC1; Signal transduction; Reactive oxygen species; MAPK/ERK pathway; Guanine nucleotide exchange factor; Intracellular; Chemistry; Cell growth; Biology; Receptor; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001699502,0.0003499709,0.0002485965,0.000263,0.0002846417,0.0003224725,0.0001820815,0.000289093,0.0007889358],"category_scores_gemma":[0.0001199547,0.0001324271,0.0003726343,0.0001119642,0.0002434038,0.0003664868,0.0003414257,0.0006529173,0.0003789139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002147485,"about_ca_system_score_gemma":0.0001492206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002015786,"about_ca_topic_score_gemma":0.0001948601,"domain_scores_codex":[0.9998455,0.0000334016,0.00001135794,0.0000297518,0.0000393772,0.00004067993],"domain_scores_gemma":[0.9999239,0.00001000542,0.00002048466,0.000008571741,0.00001541817,0.00002155252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001031354,0.00001785969,0.0001496943,0.00004466189,0.000003597821,0.0000688822,0.00002176126,0.00007952205,0.9973941,0.0004792419,0.00006969655,0.001567931],"study_design_scores_gemma":[0.00002258319,0.0001823728,0.006891752,0.00001173073,0.00002616083,0.000550141,0.00006672647,0.003336753,0.9754605,0.000630201,0.01280637,0.00001464967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9683617,0.0096448,0.01518385,0.0005673661,0.0002475745,0.0000454561,0.0003563016,0.0003289951,0.005263962],"genre_scores_gemma":[0.9914824,0.002919424,0.002975796,0.00006936172,0.0000512755,0.0000296328,0.000239845,0.00002633096,0.002205986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007889358,"threshold_uncertainty_score":0.002639234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01881808594346483,"score_gpt":0.2098593011391454,"score_spread":0.1910412151956806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}