{"id":"W2273636061","doi":"10.1007/978-1-59745-385-1_8","title":"Biomarkers and Surrogates in Clinical Studies","year":2008,"lang":"en","type":"review","venue":"Methods in molecular biology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"","keywords":"History","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02713679,0.002328191,0.006614437,0.007918885,0.0005946312,0.004390923,0.002572364,0.004809342,0.004004123],"category_scores_gemma":[0.04068081,0.0009197903,0.001984047,0.009597302,0.006051091,0.005669126,0.002729205,0.007475757,0.002116319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002988078,"about_ca_system_score_gemma":0.004303924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001058421,"about_ca_topic_score_gemma":0.0008340513,"domain_scores_codex":[0.979659,0.01356459,0.002436131,0.001032268,0.003104619,0.0002034786],"domain_scores_gemma":[0.9456326,0.04637647,0.003268953,0.0014037,0.002797524,0.0005206991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001875279,0.00009506832,0.0006466788,0.04024576,0.0006702637,0.0003517389,0.0002931219,0.001517849,0.0002873449,0.09962437,0.04144282,0.8146374],"study_design_scores_gemma":[0.0001323833,0.0001902417,0.001537515,0.05240704,0.0004738798,0.00183031,0.0002632823,0.0007231085,0.0003430251,0.1670939,0.7748733,0.0001320551],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003727171,0.9957436,0.001621281,0.001333406,0.0005902869,0.00002378663,0.00002520795,0.000009246385,0.0006159564],"genre_scores_gemma":[0.001322731,0.9926225,0.002825502,0.001305808,0.001378614,0.000135486,0.00005606492,0.000007167992,0.0003460991],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02713679,"threshold_uncertainty_score":0.1435148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1747216621043565,"score_gpt":0.567863579266352,"score_spread":0.3931419171619955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}