{"id":"W2273934916","doi":"10.1200/jco.2015.33.15_suppl.tps3090","title":"Phase I study to evaluate the safety and efficacy of MEDI4736 in combination with tremelimumab in patients with recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN).","year":2015,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Tremelimumab; Medicine; Durvalumab; Immunogenicity; Immunotherapy; Oncology; Immune checkpoint; Antigen; Internal medicine; Ipilimumab; Cancer research; Cancer; Immunology; Nivolumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00100903,0.001138845,0.002154761,0.000397294,0.0003557435,0.0008891422,0.0008145269,0.00105621,0.004881835],"category_scores_gemma":[0.0005887858,0.0006064606,0.001395616,0.0004329568,0.0007757158,0.000773936,0.0003416183,0.002556487,0.001560626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009687316,"about_ca_system_score_gemma":0.001689074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000949152,"about_ca_topic_score_gemma":0.0018275,"domain_scores_codex":[0.9997479,0.0000923351,0.00001119162,0.00004764185,0.00002615141,0.00007474722],"domain_scores_gemma":[0.9995838,0.00004154916,0.00007323313,0.00003872948,0.0000247177,0.0002380353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6936346,0.09316665,0.008199662,0.001250967,0.001908876,0.0005369401,0.0003433265,0.003444652,0.08233933,0.0004018898,0.004950399,0.1098227],"study_design_scores_gemma":[0.3093943,0.6695547,0.009853778,0.00003601773,0.0006866393,0.0004753455,0.00006413976,0.001300293,0.004939512,0.0002189835,0.003450406,0.00002581269],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895687,0.002875566,0.0006306327,0.0004281615,0.0001574297,0.002926592,0.001351055,0.0001233889,0.00193844],"genre_scores_gemma":[0.9863164,0.002456875,0.001730918,0.0007798197,0.000196597,0.003095109,0.002166969,0.00003581062,0.003221666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004881835,"threshold_uncertainty_score":0.01633137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1428010390137872,"score_gpt":0.4669355917007312,"score_spread":0.324134552686944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}