{"id":"W2274120501","doi":"10.1186/s12885-016-2149-9","title":"Promoter methylation of ITF2, but not APC, is associated with microsatellite instability in two populations of colorectal cancer patients","year":2016,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Cancer Care Ontario; Memorial University of Newfoundland; Occupational Cancer Research Centre; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; University Health Network; University of Toronto","funders":"National Cancer Institute; Canadian Institutes of Health Research; University of Toronto","keywords":"MLH1; Microsatellite instability; Adenomatous polyposis coli; DNA methylation; Epigenetics; Wnt signaling pathway; Colorectal cancer; Cancer research; Methylation; Carcinogenesis; Biology; Cancer; Familial adenomatous polyposis; DNA mismatch repair; Medicine; Genetics; Gene; Gene expression; Microsatellite","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002049623,0.0001819968,0.0004592915,0.0001352108,0.00002388323,0.00000386435,0.00008640299,0.0001068269,0.0005780989],"category_scores_gemma":[0.0002456685,0.0001238221,0.00008407782,0.0004203507,0.0001865687,0.000091257,0.00004011874,0.0001085555,0.000001891855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007973947,"about_ca_system_score_gemma":0.0005162442,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00440372,"about_ca_topic_score_gemma":0.02445159,"domain_scores_codex":[0.9983301,0.00009208119,0.0005446592,0.0003450699,0.0004326112,0.0002554645],"domain_scores_gemma":[0.9986351,0.0001311011,0.0003733519,0.0002284615,0.0005594177,0.00007261821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009963841,0.0002375025,0.8418941,0.0000860442,0.00005432731,3.404763e-7,0.0006295649,0.00005790586,0.1519927,0.000004398324,0.0000356597,0.00401102],"study_design_scores_gemma":[0.002780764,0.0002424602,0.6538118,0.0003702677,0.00006584582,2.687704e-7,0.0000125115,0.00007225354,0.342461,0.0000412742,0.0000377563,0.0001038795],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975811,0.0002048932,0.00005734294,0.000172538,0.0002444517,0.0009888955,0.000576907,0.00001765018,0.0001562482],"genre_scores_gemma":[0.9986686,0.0000457669,0.0007074669,0.00007897792,0.00003038124,0.0001980986,0.00002475064,0.00002975549,0.0002162615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1904683,"threshold_uncertainty_score":0.9933496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03965298696681769,"score_gpt":0.3246923399024984,"score_spread":0.2850393529356807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}