{"id":"W227417487","doi":"10.1007/s10549-015-3419-y","title":"Second primary breast cancer in BRCA1 and BRCA2 mutation carriers: 10-year cumulative incidence in the Breast Cancer Family Registry","year":2015,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"Public Health Ontario; University of Toronto; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"National Cancer Institute","keywords":"Breast cancer; Medicine; Cancer; Oncology; Incidence (geometry); Internal medicine; Cumulative incidence; Cancer registry; Family history; Gynecology; Cohort","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006353441,0.0003019134,0.0005543845,0.002117041,0.0004962225,0.0007101389,0.0005805945,0.0006253538,0.002797488],"category_scores_gemma":[0.001751114,0.0004680973,0.0008105067,0.002566344,0.0001814951,0.000758636,0.0006141939,0.0006050175,0.0007266554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000473647,"about_ca_system_score_gemma":0.0006846338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02985674,"about_ca_topic_score_gemma":0.02610133,"domain_scores_codex":[0.9994098,0.0001001162,0.00008013773,0.0002002168,0.00009068471,0.000119034],"domain_scores_gemma":[0.9983299,0.0002106683,0.0006755143,0.0002084221,0.0002627017,0.0003128025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00008858986,0.00002034223,0.9981291,0.00001003123,0.00006115828,0.0001038042,0.00003531296,0.00005748819,0.00008774459,0.00001979208,0.0004895188,0.0008970823],"study_design_scores_gemma":[0.000005072819,0.00003193554,0.998668,0.000006344302,0.00005022177,0.000546821,0.0001459498,0.0001475795,0.00005049292,0.00001506938,0.000327602,0.000004905457],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847053,0.001044856,0.0002583932,0.0001119552,0.00002157868,0.00001443667,0.01206807,0.00004662289,0.001728801],"genre_scores_gemma":[0.9902277,0.0009495578,0.0001160046,0.00003818912,0.00002419281,0.00001773407,0.007539481,0.00001077965,0.001076291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02985674,"threshold_uncertainty_score":0.05936593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04440823097639967,"score_gpt":0.3617064162398202,"score_spread":0.3172981852634205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}