{"id":"W2274225803","doi":"10.1021/acs.biochem.5b01078","title":"Backbone Flexibility Influences Nucleotide Incorporation by Human Translesion DNA Polymerase η opposite Intrastrand Cross-Linked DNA","year":2015,"lang":"en","type":"article","venue":"Biochemistry","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"DNA polymerase; DNA; Nucleotide; DNA clamp; Polymerase; Chemistry; Flexibility (engineering); Biophysics; Genetics; Cell biology; Molecular biology; Biology; Biochemistry; Polymerase chain reaction; Gene; Reverse transcriptase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002068133,0.0001990527,0.0001334586,0.00007979116,0.0000621107,0.0003422748,0.0001013671,0.0001695342,0.0005784729],"category_scores_gemma":[0.0005088026,0.0001622068,0.0001238183,0.00008525158,0.0001679354,0.0002355563,0.0001325133,0.000243276,0.0001827564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002048408,"about_ca_system_score_gemma":0.0001424973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004319563,"about_ca_topic_score_gemma":0.0006044149,"domain_scores_codex":[0.9998951,0.00002283832,0.000007707729,0.00002783889,0.00002495524,0.00002152347],"domain_scores_gemma":[0.9997907,0.00008738143,0.0000635219,0.00001098057,0.00001607156,0.00003135545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001845152,0.00001972643,0.0006941436,0.00002501484,0.000006966019,0.00003160131,0.00003621633,0.0003608025,0.9972005,0.00007622473,0.000009665117,0.001354688],"study_design_scores_gemma":[0.000006267713,0.0003964115,0.00218309,0.000004729417,0.0000116836,0.00004491406,0.00002512897,0.001414486,0.9955608,0.00002211851,0.0003248417,0.000005512753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992894,0.0001684023,0.0002838263,0.000006636174,0.000002656228,0.00000279703,0.00001413285,0.000006296733,0.0002258398],"genre_scores_gemma":[0.9991992,0.0001673323,0.0003021187,0.00000602099,0.000001214235,0.000002148353,0.00004471806,0.000004835422,0.0002723723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005784729,"threshold_uncertainty_score":0.001935124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02171281713111484,"score_gpt":0.2906136809801012,"score_spread":0.2689008638489864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}