{"id":"W2274261168","doi":"10.1016/j.bbamem.2016.02.024","title":"Substitutions mimicking deimination and phosphorylation of 18.5-kDa myelin basic protein exert local structural effects that subtly influence its global folding","year":2016,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Biomembranes","topic":"Electron Spin Resonance Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto; University of Guelph","funders":"Max-Planck-Gesellschaft; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Myelin basic protein; Chemistry; Biophysics; Myelin; Citrullination; Conformational change; Protein folding; Crystallography; Biochemistry; Biology; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001511275,0.0003799747,0.0003421449,0.00009745105,0.0002066709,0.0000446616,0.0002738628,0.0002194967,0.000003894361],"category_scores_gemma":[0.000151902,0.0002972789,0.0001323121,0.0003435578,0.0005571038,0.0000611637,0.0001927312,0.00008410159,0.000004180785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007405935,"about_ca_system_score_gemma":0.0001176658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004880391,"about_ca_topic_score_gemma":0.000038452,"domain_scores_codex":[0.9981351,0.000107903,0.0003424379,0.0006712066,0.0002992185,0.0004441738],"domain_scores_gemma":[0.998999,0.00005570624,0.0003062974,0.0003481493,0.0001957163,0.00009515428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001964968,0.00003915983,0.0003268177,0.0001625494,0.00009587495,0.000001612652,0.00006664477,0.000005492102,0.9937866,0.0004290274,0.00002988623,0.004859809],"study_design_scores_gemma":[0.00081906,0.0002915377,0.05920595,0.0002678163,0.00005613296,0.00001091249,0.00003536202,0.00006869865,0.9386247,0.0001614515,0.00009239874,0.0003659888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996464,0.001692638,0.0003998964,0.0005216241,0.0001097067,0.0006293244,0.00009459096,0.00004524861,0.00004301294],"genre_scores_gemma":[0.9986428,0.0006794332,0.0002957933,0.00006968651,0.0001030377,0.00007268139,0.00006527452,0.00002880025,0.00004249772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05887913,"threshold_uncertainty_score":0.9999479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009727299231447153,"score_gpt":0.2581080525069205,"score_spread":0.2483807532754733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}