{"id":"W2274633785","doi":"10.1074/jbc.m116.714782","title":"Multiple Mechanisms Contribute to the Cell Growth Defects Imparted by Human Telomerase Insertion in Fingers Domain Mutations Associated with Premature Aging Diseases","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Telomerase; Telomere; Dyskeratosis congenita; Telomerase reverse transcriptase; Biology; Cell growth; Mutation; Stem cell; Processivity; Premature aging; Cancer research; Protein subunit; Telomerase RNA component; Genetics; Cell biology; DNA; DNA replication; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002153223,0.0008772648,0.0002927663,0.0005137302,0.0002402046,0.0004073179,0.0003061377,0.0004435426,0.001161012],"category_scores_gemma":[0.0001797126,0.0001713765,0.0003346204,0.0001938812,0.00035223,0.0003120914,0.0004427609,0.0004482492,0.0003830836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000275229,"about_ca_system_score_gemma":0.0002006476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001948834,"about_ca_topic_score_gemma":0.0002315343,"domain_scores_codex":[0.9998606,0.00001909213,0.00002326645,0.000032661,0.00003986033,0.00002447547],"domain_scores_gemma":[0.9998308,0.00002530303,0.00007724619,0.00002233406,0.0000117662,0.00003245573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001353761,0.00002465479,0.002807279,0.00005331924,0.00001499064,0.0005556668,0.00001766494,0.0001833626,0.9928079,0.0002725932,0.00003341607,0.003093784],"study_design_scores_gemma":[0.00003651694,0.0002909024,0.05254129,0.00003193578,0.00008734957,0.008774407,0.00005649795,0.00221456,0.9311565,0.0008361853,0.003954371,0.00001949283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903853,0.00367277,0.004323296,0.0001022883,0.00002367296,0.00001737861,0.000244386,0.000139773,0.00109116],"genre_scores_gemma":[0.9968658,0.00108874,0.00133634,0.00002277642,0.00001174545,0.00001064766,0.0001791651,0.000009853302,0.0004749162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001161012,"threshold_uncertainty_score":0.003883958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0107597167079922,"score_gpt":0.2368081157067025,"score_spread":0.2260483989987103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}