{"id":"W2274774261","doi":"10.1038/leu.2016.4","title":"Lysosomotropic agents selectively target chronic lymphocytic leukemia cells due to altered sphingolipid metabolism","year":2016,"lang":"en","type":"article","venue":"Leukemia","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of Manitoba; CancerCare Manitoba","funders":"","keywords":"Sphingosine; Chronic lymphocytic leukemia; Sphingolipid; Lysosome; Biology; Sphingosine kinase; Programmed cell death; Cancer cell; Sphingosine-1-phosphate; Cell biology; Leukemia; Cancer research; Apoptosis; Biochemistry; Immunology; Cancer; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0005538034,0.0008420453,0.001397189,0.0006469251,0.0002741139,0.000110415,0.0009342414,0.0004879403,0.002181386],"category_scores_gemma":[0.0005883836,0.0006167783,0.0004553614,0.00125385,0.0003054043,0.0003856258,0.0005662953,0.0005455844,0.006593426],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.3570014,"about_ca_system_score_gemma":0.0763277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002436255,"about_ca_topic_score_gemma":0.0001020035,"domain_scores_codex":[0.9932565,0.0002438967,0.001004423,0.001609129,0.001609487,0.002276548],"domain_scores_gemma":[0.9956738,0.0003848403,0.0002499562,0.001795461,0.0004266178,0.001469315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002503806,0.0001705907,0.0003557423,0.001163841,0.001473739,0.003011016,0.001385549,0.00306326,0.829982,0.001158738,0.1050755,0.05065617],"study_design_scores_gemma":[0.07881222,0.00136244,0.01362384,0.001364598,0.0005455064,0.002302544,0.00006858251,0.03325057,0.6270427,0.0009614521,0.2387073,0.00195819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850924,0.0008469597,0.003833252,0.0006227745,0.001486346,0.00200164,0.0000811654,0.0005783236,0.005457115],"genre_scores_gemma":[0.9696233,0.0002570288,0.002779413,0.002023226,0.003300658,0.0002640333,0.00003380713,0.0002583014,0.02146028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2806737,"threshold_uncertainty_score":0.9996284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01793693545163691,"score_gpt":0.2793650345160461,"score_spread":0.2614280990644092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}