{"id":"W2274984109","doi":"10.1371/journal.pone.0145833","title":"Improving the Immunogenicity of the Mycobacterium bovis BCG Vaccine by Non-Genetic Bacterial Surface Decoration Using the Avidin-Biotin System","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Vancouver Coastal Health","funders":"Canadian Institutes of Health Research; British Columbia Lung Association","keywords":"Immunogenicity; Antigen; Avidin; Biotinylation; Mycobacterium bovis; Biology; Ovalbumin; Fusion protein; MHC class I; Antigen presentation; Epitope; Mycobacterium tuberculosis; Tuberculosis vaccines; Immune system; Virology; Microbiology; Major histocompatibility complex; Recombinant DNA; Molecular biology; Immunology; T cell; Gene; Tuberculosis; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000223852,0.000348632,0.0002292569,0.0001649179,0.0001164608,0.0002697411,0.00021187,0.0004323575,0.0006923843],"category_scores_gemma":[0.00017839,0.0001422831,0.0002833485,0.0001190585,0.0001614981,0.0002497744,0.0002887807,0.0004948472,0.0003908501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001743805,"about_ca_system_score_gemma":0.0001410934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000287862,"about_ca_topic_score_gemma":0.0003299913,"domain_scores_codex":[0.999817,0.00003443806,0.00001307817,0.00002761587,0.00006583877,0.00004207088],"domain_scores_gemma":[0.9999316,0.00001431739,0.00001816017,0.000008329611,0.00001472993,0.00001282143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001471138,0.00001293528,0.0000454028,0.00002363991,0.000001531535,0.00001225804,0.000005418053,0.00004015628,0.9988452,0.0000398518,0.000008962093,0.0009497968],"study_design_scores_gemma":[0.00000493604,0.0002103286,0.0007389557,0.000003830355,0.000009426794,0.0001263383,0.000006928592,0.0008657371,0.9967517,0.00002256773,0.001256669,0.000002687292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768306,0.002249229,0.01919764,0.0001444529,0.00004081159,0.00005218593,0.00005129491,0.0001038055,0.001329914],"genre_scores_gemma":[0.9849193,0.001085504,0.01203204,0.00008835075,0.00001157962,0.00002565953,0.0001385955,0.00002944032,0.001669441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006923843,"threshold_uncertainty_score":0.002316296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05425896379088404,"score_gpt":0.2731744113320799,"score_spread":0.2189154475411958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}